Apoptotic Response of Human Mesenchymal Stem Cells against Dose Dependent Exposure to Organophosphate Pesticide-Monocrotophos


Affiliations

  • System Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), MG Marg, Lucknow, Uttar Pradesh, 226001, India
  • Academy of Scientific and Innovative Research, CSIR-IITR Campus, Lucknow, Uttar Pradesh, 226001, India

Abstract

The severe health implications associated with the exposure of organophosphate pesticides are highly pronounced owing to their indiscriminate use. Monocrotophos, a predominantly used organophosphate pesticide, is a hazardous chemical that predisposes the exposed population towards multiple health disorders. We investigated the toxic effects of MCP on human mesenchymal stem cells to ascertain its overall detrimental effects on the normal physiology. There was a remarkable reduction in the cell viability accompanied with increased oxidative stress and mitochondrial dysfunctions with the increasing exposure concentrations. The decreased cell viability is probably an outcome of monocrotophos induced apoptotic cell death indicated by elevated expression of Bax and caspase-3 and reduced BCl2 expression and as such calls for a stringent abatement in its haphazard use to prevent the incidence of many life threatening ailments.

Keywords

Apoptosis, Cytotoxicity, Monocrotophos, Stem Cells

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References

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