Association of Cytokine TNF-α in Development of Osteoarthritis: A Comprehensive Study


Affiliations

  • University of Lucknow, Department of Zoology, Experimental and Public Health Laboratory, Lucknow, 226007, India
  • University of Lucknow, Department of Zoology, Molecular Endocrinology Lab, Lucknow, 226007, India
  • King George Medical University, Department of Orthopaedics, Lucknow, 226003, India

Abstract

Osteo-Arthritis (OA) is a disease of joints affecting the normal functions of joint and causes physical disability. Many factors are responsible for development of osteoarthritis including over age, obesity, gender, drug abuse, over load on joints and genetic factors. OA causes health problems and impairs the quality of life with increased economic burden across the world. Apart from the pro-inflammatory role of cytokine Interleukin-1 (IL-1) in osteoarthritis, Tumor necrosis factor-alpha (TNF-α) is also involved in the progression of osteoarthritis. Members of TNF family are secreted from lymphocytes and natural killer cells but in OA patients it is also secreted from chondrocyte cells to influence the catabolic processes in Extra Cellular Matrix (ECM) by inducing the activity of matrix metaloproteinases (MMPs). In promoter region, most of the Single nucleotide polymorphisms (SNPs) of TNF-α located on -863, -857, -308, and -238. These SNPs are involved in various diseases including OA, rheumatoid Arthritis, systemic lupus erythematosus etc. Significance association of SNP -G308A of the TNF-α gene in OA has been observed in various studies. Aim of this mini review is to conclude the fundamental roles of TNF-α cytokine in patients with OA.

Keywords

Cytokine, Gene Variants, Osteoarthritis, Pathophysiology, TNF-α.

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