Lead Exposure on Blood Pressure and Lipid Parameters Alteration among People around Bus Terminal in Yogyakarta

Jump To References Section

Authors

  • Faculty of Medicine, Department of Public Health, Universitas Islam Indonesia, Yogyakarta – 55584 ,ID
  • Faculty of Medicine, Department of Public Health, Universitas Islam Indonesia, Yogyakarta – 55584 ,ID
  • Faculty of Medicine, Department of Public Health, Universitas Islam Indonesia, Yogyakarta – 55584 ,ID

DOI:

https://doi.org/10.18311/jeoh/2020/24825

Keywords:

Blood Pressure, Bus Terminal, Lead Exposure, Lipid Parameter
Blood Pressure

Abstract

Lead is generated as residual progress of vehicle or factory process. The excessive amount of lead has several impacts on human health system namely on cardiovascular, respiratory, endocrine and metabolic system through damaging enzymatic process and Reactive Oxygen Species (ROS). The aim of this study is to search the correlation of lead exposure on blood pressure and lipid parameters alteration among people around bus terminal in Yogyakarta. This study is a cross sectional research design. According to calculation of sample size, 71 respondents had fulfilled the inclusion criteria such as: Agree to be respondents, 6 hours fasting prior to take data, age >18 years old and had history of staying nearby bus terminal for more than one year. The variables divided into two, independent variable is lead exposure and dependent variables are SBP and DBP meanwhile lipid parameters such as LDL, HDL and TG. Those variables were analyzed by linier regression. Based on linier regression was obtained that SBP (p value 0.004, r 0.33 and R square 0.11), DBP (p value 0.001 r 0.37 and R square 0.138), LDL (p value 0.002 r 0.35 and R square 0.128), HDL (p value 0.001, r 0.37 and R square 0.139) and TG (p value 0,002, r 0.36 and R square 0.130). The result of study was found that lead exposure contributed on blood pressure and lipid parameters alteration among people around bus terminal in Yogyakarta.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2020-06-24

How to Cite

Soleman, S. R., Andini, S. A., & Edi, L. C. (2020). Lead Exposure on Blood Pressure and Lipid Parameters Alteration among People around Bus Terminal in Yogyakarta. Journal of Ecophysiology and Occupational Health, 20(1&2), 45–49. https://doi.org/10.18311/jeoh/2020/24825

Issue

Section

Articles
Received 2020-01-26
Accepted 2020-02-25
Published 2020-06-24

 

References

Abadin H, Ashizawa A, Stevens YW, Llados F, Diamond G, Sage G. Toxicology profile for lead. Atalanta: Agency for Toxic Substances and Disease Resgitry U.S. Department of Health and Human Services; 2007.

Lange J. Lead: An environmental neurotoxic agent. J Headache Pain Manag. 2017; 2(No.3:13):1–2. https://www.researchgate.net/publication/321752254

Sciences NI of EH. Lead and your health. https://www.niehs.nih.gov/health/materials/lead_and_your_health_508.pdf

Park SK, Schwartz J, Weisskopf M, Sparrow D, Vokonas PS, Wright RO. Low-level lead exposure , metabolic syndrome and heart rate variability: The VA normative aging study. Environ Heal Perpectives. 2006; 114(11):1718–24. PMid: 17107858 PMCid: PMC1665394. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC1665394/ https://doi.org/10.1289/ehp.8992

Pruss-üstün A, Fewtrell L, Landrigan PJ, Ayuso-mateos JL. Lead exposure. Comparative Quantification of Health Risks. Vol 2. Geneva: WHO; 194AD:1496-1539. https://www.apps.who.int"ºiris"ºbitstream"º9241580348_eng_Volume1

Lee D. Evidence of the possible harm of endocrine-disrupting chemicals in humans: Ongoing debates and key issues. Endocrinol Metab. 2018; 33:44–52. PMid: 29589387 PMCid: PMC5874194.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874194/ https://doi.org/10.3803/EnM.2018.33.1.44

Vaziri N. Mechanisms of lead-induced hypertension and cardiovascular disease. Am J Physiol. 2008; 295(2):454–65. PMid: 18567711 PMCid: PMC2519216. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519216/ https://doi.org/10.1152/ajpheart.00158.2008

Furieri LB, Bra G, Vescovi A, Stefanon I, Vassallo DV, Vinı M. Chronic lead exposure increases blood pressure and myocardial contractility in rats. PLoS One. 2014; 9(5):1–9. PMid: 24841481 PMCid: PMC4026242. https://doi.org/10.1371/ journal.pone.0096900 https://journals.plos.org/plosone/article/ comments?id=10.1371/journal.pone.0096900

Costa D. Air pollution. Klaassen C, ed. Casarett and Doull's Toxicology the Basic Science of Poisons. seven. Kansas: McGraw Hill; 2008. p. 1119–50.

Khalil HA, Aljubori S, Abdul-aziz S, Yaqub A. Comparative study between exposed and non exposed individuals to lead in relation to lipid profile. Tikrit Med J. 2010; 16(1):129–37. https://www.iasj.net/iasj?func=fulltext&aId=22061.

Allouche L, Hamadouche M, Touabti A, Khennouf S. Effect of long-term exposure to low or moderate lead concentrations on growth, lipid profile and liver function in albino rats. Department of Animal Physiology, Faculty of Nature and Life Sciences. Adv Biol Res (Rennes). 2011; 5(6):339–47. https://pdfs.semanticscholar.org/c5bf/3889426a40d072fc111b176235e8208820db.pdf

Sharma SV, Kumar P, Atam V, Verma A, Murthy RC. Lipid profiles with increase blood lead level: Risk of cardiovascular disease in battery workers of Lucknow City. J Indian Acad Forensic Med. 2012; 34(4):328–31. https://www.researchgate.net/publication/287850673

Assi MA, Noor M, Hezmee M, Haron AW, Yusof M, Sabri M. The detrimental effects of lead on human and animal health. Vet Sorld. 2016; 9(6):660–71. PMid: 27397992 PMCid: PMC4937060.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937060/ https://doi.org/10.14202/vetworld.2016.660-671

World Health Organization. Exposure to lead: A Major public health concern. 2019. www.who.int

Navas-acien A, Guallar E, Silbergeld EK, Rothenberg SJ. Lead exposure and cardiovascular Disease - A systematic review. Environ Heal Perpectives. 2007; 115(3):472–82. PMid: 17431501 PMCid: PMC1849948. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC1849948/ https://doi.org/10.1289/ehp.9785

Ekong EB, Jaar BG, Weaver VM. Lead-related nephrotoxicity: A review of the epidemiologic evidence. Int Soc Nephrol. 2006; 70:2074–84. PMid: 17063179. https://www.kidney-international .org/article/S0085-2538(15)51899-1/fulltext https://doi.org/10.1038/sj.ki.5001809

Mutner P, Menke A, DeSalvo K, Rabito F, Batuman V. Continued decline in blood lead levels among adults in the United States. Arch Intern Med. 2005; 165:2155–61. PMid: 16217007.

https://jamanetwork.com/journals/jamainternalmedicine/ fullarticle/486734 https://doi.org/10.1001/archinte.165.18.2155

Harari F, Sallsten G, Christensson A, Petkovic M, Hedblad B, Forsgard N et al. Blood lead levels and decreased kidney function in a population-based cohort. AJKD. 2018; 72(3):381–9. PMid: 29699886. https://www.ajkd.org/article/S0272-6386(18)30556-0/ fulltext https://doi.org/10.1053/j.ajkd.2018.02.358

Rehman K, Fatima F, Waheed I, Akash MSH. Prevalence of exposure of heavy metals and their impact on health consequences. J Cell Biochem. 2018; 119:157–84. PMid: 28643849. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.26234 https://doi.org/10.1002/jcb.26234

Bernardo RI, Sindhu RK, Quiroz Y, Vaziri ND. Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-KB activation and over expression of tubulointestinal angiotensin II.

Antioxidants Redox Signal. 2005; 7(3):1269–74. PMid: 16115032. https://www.liebertpub.com/doi/abs/10.1089/ars.2005.7.1269 https://doi.org/10.1089/ars.2005.7.1269

Ademuyiwa O, Ugbaja RN, Idumebor F, Adebawo O. Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta , Nigeria. Lipids Health Dis. 2005; 7(4):1– 7. PMid: 16191200 PMCid: PMC1253530. https://lipidworld. biomedcentral.com/articles/10.1186/1476-511X-4-19. https:// doi.org/10.1186/1476-511X-4-19

Antonowicz J, Andrzejak R, Lepetow T. Influence of heavy metals, especially lead on lipid metabolism, serum alpha-tocopherol level, total antioxidant status and erythrocyte redox status of copper smelter workers. J Anal Chem. 1998; 361:365–7. https://doi.org/10.1007/s0021600509061