Preparation and Characterization of Chitosan Tablets of Aceclofenac for Colon Targeted Drug Delivery


  • Vels University, School of Pharmaceutical Sciences, Chennai, 117, India
  • Vels University, Department of Pharmaceutics, School of Pharmaceutical Sciences, Chennai, 117, India


The present study objective was to develop novel colon specific drug delivery systems for aceclofenac using chitosan as a microbially degradable polymeric carrier and to coat the optimized batches with a pH dependent polymeric coating solution containing Eudragit L 100 and S 100 (1:4). Tablets containing four proportions of chitosan were prepared. The tablets were evaluated for physicochemical properties, drug content, dissolution, water uptake & erosion characteristics, in vitro drug release studies. The amount of aceclofenac released from the chitosan tablets at different time intervals was estimated by UV spectrophotometric method at 275nm. Eudragit coated Chitosan tablets prevented release of the aceclofenac in the physiological environment of stomach and small intestine depending on the proportion of chitosan used in the formulation. The dissolution profile and in vitro release kinetics showed that chitosan tablets were promising for controlled delivery of the drug. The findings of the present study conclusively state that chitosan tablets are promising for colon targeting of aceclofenac to synchronize the chronobiological symptoms for effective treatment of rheumatoid arthritis.


Aceclofenac, Chitosan, Eudragit Coating, Targeted Delivery, Colon Targeting, In Vitro Dissolution.

Subject Discipline

Pharmacy and Pharmacology

Full Text:


Rang HP, Dale MM. Pharmacology. 1st ed, 1988, 609; UK.

Vyas. S. P and Roop. K. Khar. Controlled Drug Delivery Concepts and Advances; Vallab Prakashan, New delhi; 218-256.

Lamprecht alf, Yamamoto Hiromitsu, Takeuchi Hirofumi, Kawashima Yoshiyaki. Design of pHsensitive tablets for the colonic delivery of the immunosuppressive drug tacrolimus. Eur. J. pharm and biopharm, 58, 2004; 37-43.

Jack Aurora and Naresh Talwar. Colonic drug delivery challenges and opportunity- An overview. Eur. Gastro. Rev (1) 2006; 165.

Rubinstein A. Approaches and opportunities in colon – specific drug delivery. Crit Rev Ther Drug Carrier Syst, 12b, 1995; 101 – 149.

Mc Leod. A.D, Friend,D.R, Tozer. T.N. Synthesis and chemical stability of glucocorticoid- dextran esters: potential prodrugs for colon-specific delivery. Int. J. Pharm, 92, 1993; 105-114.

Ashford. M, Fell J.T, Attwood. D, Sharma.H, Woodhead.P.J. An invivo investigation into the suitability of pH dependent polymers for colonic targeting. Int. J. Pharm, 95, 1993; 193-199.

Khan. M. Z, Prebeg. Z, Kurjaković. N. A pHdependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation Of drug release using Eudragit L100-55 and Eudragit S-100 combinations. J Control Release,29, 58(2), 1999; 215-222.

Fukui.E, Miyamura. N, Uemura. K, Kobayashi. M. Preparation of enteric coated timed release press coated tablets and evaluation of their function by In vitro and in vivo tests for colon targeting. Int J Pharm, 204 (1-2), 2000: 7-15.

Ashford.M, Fell. J.T. Targeting drugs to the colon: delivery systems for oral administration. J Drug Target,2(3), 1994; 241-257.

Brahma N. Singh. Modified Release solid formulations for colonic delivery. Recent patents on drug delivery and formulations. (l), 2007; 5363.

Patrick D. Wall and Ronald Melzack.. Text book of pain, 13th edn, Churchill livingstone, 2006, 653-667, UK.

Sindhu Abraham and Srinath. M. S. Development of modified pulsincap drug delivery system of metronidazole for drug targeting. Ind J Pharm Sci, 2007, 24-27.

Munira Momin, pundarikakshudu. K. In vitro studies on guar gum based formulations for the colon targeted delivery of sennosides. J Pharm Pharmaceut, 7(3), 2004; 325-331,.

Liu. L, Fishman. M.L, Kost. J, Hick. K. B. Pectin based systems for colon – specific drug delivery via oral route. Biomaterials, 246, 2003; 3333 – 43.

Gang Cheng, Feng An, Mei-Juan Zou, Jin Sun, Xiu-Hua Hao, Yun-Xia He. Time- and pHdependent colon-specific drug delivery for orally administered diclofenac sodium and 5aminosalicylic acid. World J Gastroenterol, 10 (12), 2004; 1769-1774.

Indian Pharmacoepoia.; vol II, Controller of publications, Ministry of Health ; 1996, 789801.

Chourasia. M. K, Jain. S. K. Pharmaceutical approaches to colon targeted drug delivery systems, J Pharm pharamaceut Science, 6(1), 2003; 33 – 36.

Encyclopedia of pharmaceutical technology; 3rd edition; James swarbrick; Vol.6; 2614-2629.

Evelyn Ojoe, Edna Mitie Miyauchi, Tais Cobo Viviani, Vladi Olga Consiglieri. Formulation and in vitro evaluation of theophylline-Eudragit sustained-release tablets; Brazilian Journal of Pharmaceutical Sciences, 41(3),2005.

Paharia .A, Yadav. A. K, Rai. G, Jain. S.K, Pancholi. S. S, Agrawal. G.P. Eudragit-coated Pectin Microspheres of 5-Fluorouracil for Colon Targeting. AAPS PharmSciTech. 8(1), ( 2007.

Avachat A, Kotwal V. Design and Evaluation of matrix-based controlled release tablets of diclofenac sodium and chondroitin sulfate. AAPS pharm SciTec, 8(4), 2007, 88; E1-E8.

Hadi Mehrgan and Seyed Alireza Mortazavi. The Release Behavior and Kinetic Evaluation of Diltiazem HCl from Various Hydrophilic and Plastic Based Matrices. Iran J Pharm Research, 3, 2005, 137-146.


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