Synthesis and Characterization of some Benzimidazole Derivatives Using as Anti-Hypertensive Agents


  • Maheshwara College of Pharmacy, Department of Pharmaceutical Chemistry, Patancheru, Andhra Pradesh, 500 072, India


A new series of non peptide angiotensin(A-II) receptor antagonist has been prepared. This N-(biphenyl methyl) imidazoles e.g. 5-substituted (amino) -2-phenyl-1-(2'carboxy biphenyl-4-yl) benzimidazoles differ from the previously reported and related compounds in that they produce a potent hypertensive effect upon oral administration. The earlier series were generally active only when administered intravenously. It has been found that 2'-position of biphenyl is essential. Only ortho substituted acid possess both high affinity for the AII receptor and oral anti-hypertensive potency. Following the discovery of benzimidazole derivatives, numerous structural modifications have been made to the benzimidazole nucleus to increase the anti-hypertensive potency.


Benzimidazole Derivative, Anti - Hypertensive Agent.

Subject Discipline

Pharmacy and Pharmacology

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