Assessment of Baseline Biochemical Parameters and its Correlation with Clinical Outcomes in Type 2 Diabetics

Abstract

The aim of the study is to assess the different baseline biochemical parameters required for type 2 diabetics and to correlate the same with clinical outcomes. Nine hundred Type 2 diabetic subjects aged between 30-85 years of both the genders from 3 diabetic out-patient clinics in South Bangalore were selected for the study. All the study subjects gave their informed consent. All the subjects had clinical examination with anthropometric measurements and measurements of blood pressure. Pre- tested interview schedule was used to collect the information pertaining to socio-economic and duration of diabetes. Biochemical parameters with the laboratory methods done were collected and recorded in the schedule. Among the variables studied, fasting plasma glucose was above 131 mg/dl for 64% of diabetic subjects. Postprandial plasma glucose of >201mg/d1 for 62% and poor to uncontrolled glycosylated hemoglobin (HbA1c) of greater than 8.1% were noted among 38% of the selected diabetic subjects. The individual lipid parameters were also assessed and the diabetic subjects showed higher total cholesterol (29%), triglycerides (33%), Low density Lipoprotein (59%), very Low Density Lipoprotein (15%) and lower High Density lipoprotein levels among 41% selected population. Similarly urine for microalbuminuria was noted in 71% and Albumin Creatinine Ratio (ACR) of >300 microgram/dl was found in 18% of the type 2 diabetic subjects. Also the different biochemical parameters were correlated with HbA1c and it was found that HbA1c was positively associated with all parameters except BMI and HDL at one per cent level (p 5 0.001). The parameters studied indicates that majority of the diabetic subjects are potential to develop diabetic related complications like diabetic nephropathy and underlying cardiovascular disorders. A strict glycemic control and a timely comprehensive evaluation of the biochemical parameters are considered as a potential marker to prevent diabetic prevalence to a certain level.