Effectiveness of Kampo Medicines Against Intractable Stomatitis: A Mini-Review


  • Tokushima University, Graduate Faculty of Dentistry, Department of Oral Medicine, Institute of Biomedical Sciences, Tokushima, 770-8504, Japan
  • Tokushima University, Faculty of Dentistry, Department of Oral Medicine, Institute of Biomedical Sciences, Tokushima, 770-8504, Japan


Intractable stomatitis is a chronic inflammatory disease of oral mucosa, with unclear etiopathogenesis. Kampo Medicines (KMs), i.e., Japanese herbal medicines, effectively treat stomatitis. The precise effects of KMs on intractable stomatitis are not established. We present the details of several patients with intractable stomatitis who were well-treated with KMs (i.e., Inchinkoto, Orento, Goreisan, and Byakkokaninjinto). We also review the literature on the link between intractable stomatitis and KMs. KM-related anti-inflammatory and antioxidant activity may suppress intractable stomatitis. KMs may also facilitate wound healing through increased saliva secretion. KMs may therefore be useful for the treatment of intractable stomatitis.

Subject Collection

Anti-Inflammatory Activity, Antioxidant Activity, Intractable Stomatitis, Kampo Medicines, Saliva Secretion

Subject Discipline


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