Study on Gender Specific Variability of Non-Motor Symptoms Including Cardiovascular, Sexual Disorders, Apathy, Hallucinations, Sleep Disorders and Some Miscellaneous Symptoms of Parkinson’s Disease


Affiliations

  • Government Medical College and Hospital, Amritsar, Department of Anatomy, Punjab, 143001, India
  • IVY Hospital, Department of Neurology, Amritsar –, Punjab, 143001,, India

Abstract

Introduction: Parkinson’s disease is a second most common neurodegenerative disorder after Alzheimer’s disease. It affects 1% of population over age of 50 years. Non-Motor symptoms are common in patients of Parkinson’s disease. These remain undiagnosed most of the time. Aim and Objectives: To analyse gender specific, age related and demographic variability of non-motor symptoms (Cardiovascular symptoms, sleep disorder, hallucination, sexual disorders, apathy, pain and miscellaneous symptoms) of Parkinson’s disease. Materials and Methods: Present study included 100 cases (66 males and 34 females) of Parkinson’s disease presenting at department of neurology, Dayanand Medical College and Hospital, Ludhiana. 30 questionnaires of non-motor symptoms in Hindi and Punjabi were given to patients. Gender, age, duration of non-motor symptoms, Parkinson’s phenotype and complete demographic profile of each patient taken into account for study. Thereafter result were statistically analysed for all parameters. Conclusion: It is concluded that mean age and duration of non-motor symptoms were higher in males as compared to females. It was calculated that there was positive correlation of H&Y with age and non-motor symptoms like Cardiovascular, Sleep related disorder, apathy, pain and miscellaneous symptoms. As H&Y increases there is increase in frequency and severity of symptoms. There was difference in dominant non-motor symptoms among different genders. Sexual dysfunction and sleep disorders were more prominent in males whereas cardiovascular and miscellaneous like excessive sweating were more in females.

Keywords

Parkinson’s, Non-Motor, Gender Variability

Subject Collection

north indian

Subject Discipline

neurology

Full Text:

References

Przedborski S. Etiology and Pathogenesis of Parkinson’s Disease. In: Jankovic J, Tolosa E, eds. Parkinson’s Disease and Movement Disorder 5th ed. Philadelphia: Lippincott Williams and Wilkins. 2007; 77–92.

The metric properties of a novel non-motor symptoms scale of Parkinson’s disease: result from an international pilot study. Mov Discord. 2007; 22: 1901. https://doi.org/10.1002/mds.21596 PMid:17674410

Delong MR, Juncos JL. Parkinson’s disease and other extrapyramidal movement disorders. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jamesson JL et al., editors. Harrison’s Principles of internal medicine. 17th ed. New York (NY): The McGraw- Hill Companies; 2008.p. 2549–59.

Jankovic J, Shannon KM. Movement disorders. Bradley WG, Daroff RB, Fenichel GM editors. Neurology in clinical Practice. 5th ed. Philadelphia: Butterworth- Heinemann, Elsevier; 2008.p. 2081–122. https://doi.org/10.1016/B9780-7506-7525-3.50113-8.

Chaudhuri KR, Healy DG, Schapira AHV. Non-Motor symptoms of Parkinson’s disease: Diagnosis and management. Lancet Neurol. 2008; 5: 314–24.

Tolosa E, Compta Y, Gaig C. The premotor phase of Parkinson’s disease. Relat Disord. 2007; 13(suppl): S2-7. https://doi.org/10.1016/j.parkreldis.2007.06.007PMid: 17681839.

Dehiyan A and Singh S. Study on Gender Specific Variability of Gastrointestinal, Genitourinary and Depression Related Non-Motor Symptoms of Parkinson Disease. Int jour med and Dent Sci. 2018: 7(2): 1657–1662. https://doi.org/10.18311/ijmds/2018/21429.

Chaudhuri KR, Martinez- Martin P, Brown RG, Nordu Y, Slanow, William AJ et al. The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: Result from an international pilot study. MovDisord 2007; 22: 1901–11. https://doi.org/10.1002/mds.21596.

Lolekha P, Kongkiat K. Non-motor symptoms in Thai Parkinson disease patients: prevalence, manifestation and health related quality of life. Neurology Asia. 2014; 19(2): 163–70.

Ravan A, Faiz MR, Chabria S, Gadhari M, Sankhla CS. Non motor symptoms in an Indian cohort of Parkinson’s disease patients and correlation of progression of nonmotor symptoms with motor worsening. Neurology India. 2015; 63: 166-74. https://doi.org/10.4103/00283886.156276PMid:25947979.

Song Y, Gu Z, An J. Chinese Parkinson study group. Gender difference on motor and non-motor symptoms of de novo patients with early Parkinson’s disease. Neurosci. 2014; 35: 1991-6. https://doi.org/10.1007/s10072-014-1879-1.

Krishnan S, Sarma G, Sarma S, Kishore A. Do non motor symptoms in Parkinson’s disease differ from normal ageing. MovDisord. 2011; 26: 2110-3. https://doi.org/10.1002/ mds.23826 PMid: 21661056.

Wang G, Hong Z, Cheng Q, Wang Y, Zhang J, Ma JF et al. Validation of the Chinese non motor symptoms scale for Parkinson’s disease: Result from a Chinese pilot study. Clin Neurol Neurosurg 2009; 111: 523–6. https://doi.org/10.1016/j.clineuro.2009.02.005.

Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P et al. International multicentre pilot study of the first comprehensive self completed non-motor symptoms questionnaire for Parkinson’s disease: The NMS quest study. MovDisord 2006; 21:916–23. https://doi.org/10.1002/mds.20844.

Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP et al. The PRIAMO study: A multicentre assessment of non-motor symptoms and their impact on quality of life in Parkinson’s disease. Movdiscord 2009; 24: 1641–9. https://doi.org/10.1002/mds.22643.

Chaudhuri KR, Tolosa E, Schapira A, Poewe W editors. Non-Motor symptoms of Parkinson’s Disease. Oxford, UK: Oxford University Press; 2009; 309–20. https://doi.org/10.1093/med/9780199237234.001.0001.

Shulman LM, Taback RL, Rabinstein AA, Weiner WJ. Non recognition of depression and other non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Discord. 2002; 8: 193–7. https://doi.org/10.1016/S1353-8020(01)00015-3.


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