Periodontist an Asset to Systemic Diagnosis — Diagnosing a Case of Acute Myeloid Leukaemia


Affiliations

  • Aditya Dental College, Department of Periodontics and Implantology, Beed, Maharashtra, 431122, India
  • Government Dental College and Hospital, Nagpur, Department of Periodontology, Maharashtra, 440003, India

Abstract

Acute Myeloid Leukemia (AML) is a neoplastic disease of bone marrow. AML M3 variant frequently develops swiftly and if not intervened immediately may prove fatal. This report presents a 32-year-old female who reported to dental OPD with complaint of bleeding gums and no previous medical history. On examination suspicious lesions were seen and patients was advised for full blood workup and Peripheral Blood Smear (PBS) investigations which revealed features suggestive of AML M3. The significant findings of this case are just presentation of oral manifestations, quick progression from initial symptoms to end stage and mild increase in WBC count which is uncommon for AML M3 variant. For many types of cancer, finding it early might make it uncomplicated to treat. This report outlines how a periodontist proved to be an asset in diagnosing a case of AML.


Keywords

Acute Myeloid Leukemia, Oral Manifestations, Periodontist

Subject Collection

Nagpur

Subject Discipline

Periodontology

Full Text:

References

Williams WJ, Beutler E, Erslev AJ, Lichtman MA. Hematology, 4th ed. New York: McGraw Hill; 1990. p. 243–44.

Zwan CM, Kolb EA, Reinhardt D. Collaborative efforts during progress in pediatric acute myeloid leukemia. Journal of Clinical Oncology. 2015; 33:2949–62.

Ghosh S, Shinde SC, Kumaran GS, Sapre RS, Dhond SR, Badrinath Y, et al. Haematologic and immunophenotypic profile of acute myeloid leukemia: An experience of Tata memorial hospital. Indian Journal of Cancer. 2003; 440:71– 6.

Anil S, Smaranayake LP, Nair RG, Beena VT. Gingival enlargement as a diagnostic indicator in leukaemia. Case report. Australian Dental Journal. 1996; 41:235–7. https://doi.org/10.1111/j.1834-7819.1996.tb04865.x. PMid:8870276

Bressman E, Decter JA, Chasens AI, Sackler RS. Acute myeloblastic leukemia with oral manifestations. A case report. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 1982; 54:401–3. https://doi.org/10.1016/00304220(82)90386-3

Lynch MA, Ship II. Initial oral manifestations of leukaemia. Journal of the American Dental Association. 1967; 75:932– 40. https://doi.org/10.14219/jada.archive.1967.0301. PMid:5233413

Wu J, Fantasia JE, Kaplan R. Oral manifestations of acute myelomonocyticleukemia: A case report and review of the classification of leukemias. Journal of Periodontology. 2002; 73:664–8. https://doi.org/10.1902/jop.2002.73.6.664. PMid:12083541

Dreizen S, McCredie KB, Keating MJ, Luna MA. Malignant gingival and skin infiltrates in adult leukemia. Oral Surgery, Oral Medicine, Oral Pathology. 1983; 55:572–9. https://doi.org/10.1016/0030-4220(83)90373-0

Newman, Takei, Klokkevold, Carranza. Textbook of clinical periodontology. 10th edition, Elsevier Publications; 2006. p. 702.

Jazilah W, Ariffin W, Jackson N. M3-Variant of acute promyelocytic leukaemia a case report in Malay boy. 1995 Mar; 50(1):105–7.

Golomb HM, Rowley JD, Vardiman Jw, Testa JR, Butler A. Microgranular acute promyelocytic leukemia: A distinct clinical, ultrastructural and cytogenetic entity. Blood. 1980; 55(2):253–9. https://doi.org/10.1182/blood.V55.2.253.253. PMid:6928105

Stafford R, Sonis S, Lockhart P, Sonis A. Oral pathoses as diagnostic indicators in leukemia. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 1980; 50:134–9. https://doi.org/10.1016/0030-4220(80)90200-5


Refbacks

  • There are currently no refbacks.