Genetics of Medullary Thyroid Carcinoma

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Authors

  • Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113 ,IN
  • Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113 ,IN
  • Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113 ,IN
  • Ontogenie et Reproduction, CRBR, CHUL, 2705 Boul W Lauira, Laval University Stc Roy, que, GIV 4G2 ,CA
  • Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113 ,IN

Keywords:

Calcitonin, Familial Medullary Thyrold Carcinoma, Gene Therapy, Immuno Therapy, Medullary Thyroid Carcinoma, Multiple Endocrine Neoplasia, Ret Protooncogene.

Abstract

Existing modes of diagnosis and therapy for medullary thyroid carcinoma (MTC) have limitations, informations on the genetics of familial medullary thyroid carcinoma (FMTC), a constituent of multiple endocrine neoplasia II (MEN II) syndrome may help to understand the etiology of the disease and to design gene therapy. Association between specific mutations in ret protooncogene to specific phenotypes of MEN II subjects provide vital line of due for the diagnosis of the disease. Screening of suspected/potent carriers of ret (rearranged during transformation) mutations will help to decide about the time and course of treatment. Gene therapy for MTC appears to be imminent and this review attempts to provide a comprehensive account of informations from more than hundred research articles published in this area.

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Published

2001-12-01

How to Cite

Michael Aruldhas, M., Kalpana, N., Vengatesh, G., Sakhila Banu, K., & Govindarajulu, P. (2001). Genetics of Medullary Thyroid Carcinoma. Journal of Endocrinology and Reproduction, 5(1&2), 59–76. Retrieved from http://informaticsjournals.com/index.php/jer/article/view/4435