Wound Healing Profile of Sauropus androgynus in Wistar Rats


Affiliations

  • Belgaum Institute of Medical Sciences, Department of Pharmacology, Belgaum, Karnataka, 590001, India
  • Kasturba Medical College, Department of Pharmacology, Mangalore, Karnataka, 575001, India

Abstract

Objective: To evaluate the effect of Sauropus androgynus on wound healing. Materials and Methods: Excision and incision wound models were used to evaluate the wound-healing activity of 5% Sauropus androgynus on Wistar rats of either sex. Results: Sauropus androgynus extract promoted the wound healing activity significantly in both wound models studied, while no action was seen with ointment base. It augmented wound contraction significantly (P<0.001), re-epithelization very significantly (P<0.0001) and increase in wound breaking strength (P<0.001). Histological evaluation of wound tissue showed abundant collegenation, fibroblast and lesser macrophages in animal treated with 5% Sauropus androgynus when compared to control and ointment base. Conclusion: Extract of Sauropus androgynus promotes wound-healing activity.

Keywords

Sauropus Androgynus, Wound Healing, Wound Re-Epithelization, Wound Contraction.

Subject Discipline

Pharmacy and Pharmacology

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