Protective Effect of Trianthema portulacastrum Linn Leaves on Gentamicin Induced Nephrotoxicity in Rats


Affiliations

  • C. L. Baid Metha College of Pharmacy, Department of Pharmacognosy, Chennai, Tamil Nadu, 600097, India
  • S.R.M. College of Pharmacy, Department of Pharmacology, Kanchepuram, 603203, India
  • Madras Medical College, Department of Pharmacognosy, Chennai, Tamil Nadu, 600003, India

Abstract

Objective: To evaluate the nephro protective effect of ethanolic extract of Trianthema portulacastrum leaves in gentamicin induced renal damage in rats. Materials and methods: The nephro protective activity of ethanolic extract of T.portulacastrum leaves was evaluated against gentamicin induced renal damage in rats. Various biochemical parameters were assessed and histopathological section of the kidney was taken. The protective effect was further studied from analyzing the potential of the extract to scavenge the free radicals. Results: i.p administration of ethanolic extract of T.portulacastrum restored the levels of the biochemical factors determined significantly and exhibited a significant potential to scavenge free radicals with respect to control. Conclusion: The ethanolic extract of T.portulacastrum exhibited significant (P< 0.001) nephro protective activity.

Keywords

Antioxidant, Trianthema Portulacastrum, Gentamicin, Nephrotoxicity.

Subject Discipline

Pharmacy and Pharmacology

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