Impaired Wound Healing Due to Cyclophosphamide (CLP) Alleviated by Supplemental Ginkgo biloba (GB)


  • Manipal University, Kasturba Medical College, Department of Pharmacology, Manipal, Karnataka, 576104, India


Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly(p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.


Dead Space Wounds, Excision Wounds, Granulation Tissue, Hydroxyproline

Subject Discipline

Pharmacy and Pharmacology

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