Anti-Asthmatic and Anti-Allergic Activity of Lagenaria siceraria Mol. Standley

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DOI:

https://doi.org/10.18311/jnr/2012/40

Keywords:

Lagenaria siceraria Mol. Standley, Bronchoconstriction, Compound 48/80, Mast Cell Stabilization, Paw Edema
Therapeutic Drug Monitoring

Abstract

The present attempt was aimed to evaluate the anti-asthmatic and anti-allergic activity of the aqueous extract of Lagenaria siceraria leaf (LSA) using various animal models like histamine and acetylcholine induced bronchoconstriction in Guinea pigs, compound 48/80 induced mast cell degranulation in rats and paw edema in mice. LSA exhibited significant and dose dependent bronchodilatory activity at the doses of 150 and 300 mg/kg intraperitonially (i.p.). LSA at the concentrations of 10, 20 and 30 μg/ml significantly inhibited compound 48/80 induced mast cell degranulation. The anti inflammatory activity was observed at the doses of 50, 75 and 100 mg/kg (i.p.) against compound 48/80 induced paw edema in rats. These results prove the traditional claim of the drug in treatment of asthmatic disorders.

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Published

2012-01-01

How to Cite

Jasani, N., Kapoor, M., Tripathi, N., Acharya, N. S., Acharya, S. R., & Kumar, V. (2012). Anti-Asthmatic and Anti-Allergic Activity of <I>Lagenaria siceraria</I> Mol. Standley. Journal of Natural Remedies, 12(1), 72–76. https://doi.org/10.18311/jnr/2012/40

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