A Study on the Anti-Hyperglycaemic Effect of Premna corymbosa Rottl. Roots


Affiliations

  • Institute of Pharmacy and Technology, Cuttack, Orissa, 754202, India
  • Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, 752101, India
  • Siddheswar College of Pharmaceutical Sciences,, Orissa, 756030, India

Abstract

Objective: To study the antihyperglycaemic activity of the ethanol (50% v/v) root extract of Premna corymbosa Rottl. on albino rats. Materials and methods: Antihyperglycaemic activity of the root extract was evaluated by using both normoglycaemic and alloxan induced hyperglycaemic rats at dose levels of 200 and 400 mg/kg respectively through oral route. Results: The extract was found to produce marked reduction in blood glucose concentration at tested dose levels in a dose dependant manner in both the models. However, in normoglycaemic animals, the extract at 400 mg/kg dose level produced significant reduction of blood glucose at the 8th hour of administration. Conclusion: The results of the present study justify the use of the roots of the plant for treating diabetes as suggested in folklore remedies.

Keywords

Premna corymbosa Rottl, Alloxan, Antihyperglycaemic, Normoglycaemic, Glibenclamide.

Subject Discipline

Pharmacy and Pharmacology

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