Evaluation of Tissue Protective Activity of Tinospora cordifolia Stems in Irradiated Swiss Albino Mice with 60Co Radiation


Affiliations

  • Bharat Institute of Technology, Department of Pharmacy, Meerut, Uttar Pradesh, 250103, India
  • Barkatullah University, Department of Pharmacy, Bhopal, Madhya Pradesh, 462002, India

Abstract

In the present study, wholesome tissue protective efficiency of the ethanolic extract of Tinospora cordifolia stems in mice in terms of whole body survival, genotoxicity, cell proliferation and hematological profile have been investigated. The animals were divided into four groups having six animals in each. Group I, (Control), received vehicle, Group II received orally ethanolic extract of Tinospora cordifolia (500mg/kg), Group III was irradiated with 60Co radiation (external gamma radiation of 4 GY for 24h), and animals of Group IV were irradiated with 60Co radiation (external gamma radiation of 4 GY for 24 h) and given orally ethanolic extract of Tinospora cordifolia (500mg/kg), for seven days. On the 8th day all the animals were sacrificed, the blood was collected and hematological cell profile was analyzed. Intestine was removed and its histopathology was done and their mitotic index and crypt of villi was counted. The drug shows significant tissue protective activity (P<0.05) and shows normalization in hematological cell profile in irradiated animals.

Keywords

Tissue Protective, Tinospora cordifolia, 60Co Radiation.

Subject Discipline

Pharmacy and Pharmacology

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