Hypoglycemic Properties of Ficus glomerata Fruits in Alloxan-Induced Diabetic Rats


Affiliations

  • K.L.E. Society's College of Pharmacy, Department of Pharmacognosy and Phytochemistry, Belgaum, Karnataka, 590010, India
  • Devi Ahilya Vishwavidyalaya, Department of Pharmacy, Indore, India

Abstract

Objective: To study the hypoglycaemic properties of Ficus glomerata fruits in alloxan induced diabetic rats. Materials and methods: Petroleum ether, benzene, chloroform, ethanol and aqueous extracts of F. glomerata fruits were screened for hypoglycemic properties in alloxan-induced diabetic rats. The effect was assessed by blood glucose, serum cholesterol, serum urea and serum triglyceride levels. Oral doses of petroleum ether extracts of 250 mg/kg body weight produced significant lowering of blood sugar, serum cholesterol, serum urea and serum triglyceride levels in alloxan-induced diabetic treated rats. The hypoglycemic effects were compared with those of glibenclamide. Conclusion: The present study shows that petroleum ether extracts of fruits of F. glomerata produce better hypoglycemic actions compared to other extracts.

Keywords

Acute Toxicity, Alloxan, Ficus glomerata, Hypoglycemic Activity, Moraceae.

Subject Discipline

Pharmacy and Pharmacology

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