Evaluation of Antipyretic and Anti-inflammatory Activity of Aqueous Extract of Leptadenia Reticulata in Animal Models


Affiliations

  • Gokaraju Rangaraju College of Pharmacy, Department of Pharmacology, Bachupally, Hyderabad, Andhra Pradesh, 500090, India
  • Gokaraju Rangaraju College of Pharmacy, Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, 500090, India

Abstract

Objective: To study the antipyretic and anti-inflammatory effects of the Aqueous Extract of Leptadenia Reticulata (AELR) in different animal models. Materials and Methods: Acute toxicity studies were performed and extract was found to be safe upto 2000 mg/kg. Two doses were selected for the "evaluation of antipyretic and anti-inflammatory activity of aqueous extract of Leptadenia reticulata in animal models" i.e 200 mg/kg and 400 mg/kg b. w. Antipyretic activity was evaluated using baker's yeast induced pyrexia in albino rats and cow milk induced pyrexia in albino rabbits. Anti-inflammatory activity was evaluated using carrageenan induced paw edema and turpentine oil induced paw edema in albino rats. Results: In all the animal models AELR at the dose of 200 mg/kg b.w and 400 mg/kg b.w showed significant (P<0.01) antipyretic and anti-inflammatory activity. Conclusion: These finding could justify the inclusion of aqueous extract of Leptadenia reticulata in the management of pyrexia and inflammation.

Keywords

Baker's Yeast, Cow Milk, Carrageenan, Leptadenia reticulata, Turpentine Oil

Subject Discipline

Pharmacy and Pharmacology

Full Text:

References

Hatapakki BC, Hukkeri VI. Antipyretic activity of root of Marsdenia tenacissima in rats. Journal of Natural Remedies. 2011; 11(2):98–102.

Kalabharathi HL, Suresh RN, Pragathi B, Pushpa VH, Satish AM. Anti-inflammatory activity of fresh tulsi leaves (Ocimum sanctum) in albino rats. International Journal of Pharma and Bio Sciences. 2011; 2(4):45–9.

Bawra B, Dixit M, Chauhan NS, Dixit VK and Saraf DK. Leptadenia reticulata a Rasayana herbs. Asian Journal of Plant Sciences. 2010; 9(6):314–9.

Rani S, Manavalan D, Killimozhi K, Balamurugan. Preliminary study on the anti-implantation activity of Leptadenia reticulata in female rats. International Journal of Pharma Technical Research. 2009; 1(4):1403–5.

Khandelwal KR. Practical pharmacognosy techniques and experiments. 2005. p. 30–149.

OECD Guideline for testing of chemicals (425). 2001. p. 1–26.

Olorunfemi OJ, Nworah DC, Egwurugwu JN, Hart VO. Evaluation of anti-inflammatory, analgesic and antipyretic effect of Mangifera indica leaf extract on fever-induced albino rats (Wistar). British Journal of Pharmacology and Toxicology. 2012; 3(2):54–7.

Emdad Hossain, Subhash Mandal C, Gupta JK. Phytochemical screening and in-vivo antipyretic activity of the methanol leaf-extract of Bombax malabaricum DC (Bombacaceae). Tropical Journal of Pharmaceutical Research. 2011; 10(1):55–60.

Thirumal M, Surya Srimanthula, Kishore G, Vadivelan R, Anand Kumar AVS. Analgesic and antipyretic effects of aqueous extract from Clerodendrum inerme (L.) Gaertn. leaves in animal models. Der Pharmacia Lettre. 2013; 5(2):315–23.

Singh S, Nair V, Gupta YK. Antiarthritic activity of Majoon Suranjan (a polyherbal Unani formulation) in rat. Indian Journal of Medical Research. 2011; 134:384–8.

Mahalakshmi K, Natesan SK, Parthiban KG, Sekar G. Anti-inflammatory and antipyretic activity of Fioria vitifoli. International Current Pharmaceutical Journal. 2013; 2(7):119–21.


Refbacks

  • There are currently no refbacks.