Active Cytotoxic Compounds and Essential Oil from Bougainvillea Alba

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Authors

  • ,EG
  • ,EG
  • ,EG
  • ,EG
  • ,EG

DOI:

https://doi.org/10.18311/jnr/2015/486

Keywords:

Bougainvillea alba, Nyctaginaceae, isolation, essential oil, SRB assay
Therapeutic Drug Monitoring

Abstract

Chemical analysis of methanol extract of flowers and leaves of Bougainvillea alba led to isolation of four compounds identified as 3', 4', 6 - trimethoxy, 5 – hydroxyl 7-prenyl 3-O- (feruloyl (1→2) - rhamnpyranosyl) flavone[1], 3-O β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl (1→3”) β-D-glucopyranosyl (1→3”') α-L–xylopyrenoside [2], Lepidolide [3], E feruloyl 3-O- Coumaroyl α-L Rhamnopyranoside [4]. In addition, two oil fractions, the major identified components of oil are Elemene, Lanceol , Nerolidol , Methyl palmitate and Abietatriene. Cytotoxic activity of methanol extract of both leaves and flowers of Bougainvillea alba, isolated compounds and oil fractions were determined using the SRB Assay on human tumor cell line (Hepatocyte generation 2, HepG2). The isolated compounds showed cytotoxic activity at LC50 15.2, 17.2, 15.6 and 2.82 μg/ml for compound 1,2, 3 and 4 respectively, while the two oil fraction showed activity at 2.67 μg/ml.

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Author Biography

Laila A. Refahy

Medicinal Chemistry Department

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Published

2015-01-28

How to Cite

EL-Deeb, A.- nabi E., Abdel-Aleem, I. M., El-Amin, S. M., Refahy, L. A., & El-Shazly, M. A. (2015). Active Cytotoxic Compounds and Essential Oil from <i>Bougainvillea Alba</i>. Journal of Natural Remedies, 15(1), 49–57. https://doi.org/10.18311/jnr/2015/486

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Articles
Received 2015-10-08
Accepted 2015-12-07
Published 2015-01-28

 

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