A Pharmacognostical study on Fumaria parviflora Lamk.


Affiliations

  • L. M. College of Pharmacy, Department of Pharmacognosy and Phytochemistry, Ahmedabad, Gujarat, 380009, India

Abstract

Fumaria parviflora Lamk., is a valued herb in Ayurvedic medicine and is used as Parpata by majority of Ayurvedic practitioners amongst the other plant sources mentioned under the same common name. It is found in many parts of India from Indo-Gangetic plain and Nepal down to the Nilgiri Mountains. The whole plant is diuretic, diaphoretic, aperient, laxative and anthelmintic. It is used as antipyretic, blood purifier and in skin disorders. In the present study, physico-chemical parameters were established for identification of the drug. Protopine and β-sitosterol were quantified by validated HPTLC method, developed using precoated silica gel plates as a stationary phase and toluene: ethyl acetate: diethyl amine (7: 2: 1) and toluene: methanol (9.4: 0.6) as a mobile phase respectively. It is a diffuse, annual herb with thin winged stem; alternate leaf finely divided into small, linear lanceolate segments, small white or pink flowers with purplish tips. Microscopically root can be characterized by the presence of centrally located diarch primary xylem encircled by wide secondary xylem occupying major area and a narrow cork; stem by collenchymatous hypodermis, vascular bundle capped with lignified pericyclic fibres and hollow pith; leaf by vascular bundles with groups of sclerenchyma underneath the phloem and narrow spongy parenchymatous lamina. Powder can be typified by xylem vessels with varied thickening, lignified and thick walled testa and spherical pollen grains. The plant was found to be rich in alkaloids. The amount of protopine and β-sitosterol were found to be 0.47 – 0.50% w/w and 0.23 – 0.26% w/w.   The quality parameters and HPTLC method developed would serve as useful gauge in standardization of Fumaria parviflora.


Keywords

Fumaria parviflora, HPTLC, Protopine, β-Sitosterol

Subject Discipline

Pharmacy and Pharmacology

Full Text:

References

Satyavati GV, Gupta AK, Tandon N. Medicinal Plants of India. Vol. I. New Delhi: Indian Council of Medical Research; 1976, 423-5.

Anonymous. The Ayurvedic Pharmacopoeia of India. Part I. Vol. IV. 1st ed. New Delhi: Government of India, Ministry of Health and Family Welfare, Department of Indian System of Medicine and Homoeopathy; 2004, 84-6.

Anonymous. Fumaria parviflora Lam. In: Khare CP, editor. Indian Medicinal Plants. New York: Springer-Verlag Berlin/Heidelberg; 2007, 275.

Akhtar MS, Khan QM, Khaliq T. Effects of Euphorbia prostrata and Fumaria parviflora in normoglycaemic and alloxan-treated hyperglycaemic. Planta Med. 1984; 50: 138-42.

Gilani AH, Janbaz KH, Akhtar MS. Selective protective effect of an extract from Fumaria parviflora on paracetamol-induced hepatotoxicity. Gen Pharmacol. 1996; 27: 979-83.

Khattak SG, Gilani SN, Ikram M. Antipyretic studies on some indigenous Pakistani medicinal plants. J Ethnopharmacol. 1985; 14: 45-51.

Sener B, Orhan I. Molecular diversity in the bioactive compounds from Turkish plants - evaluation of acetylcholinesterase inhibitory activity of Fumaria species. J Chem Soc of Pak. 2004; 26: 313-5.

Al-Shaibani IRM, Phulan MS, Shiekh M. Anthelmintic Activity of Fumaria parviflora (Fumariaceae) against gastrointestinal nematodes of sheep. Int J Agric Biol. 2009; 11: 431–6.

Bhattacharya SK, Lal R, Sanyal AK, Dasgupta B, Das PK. Preliminary pharmacological studies on the total tertiary alkaloids of Fumaria parviflora. J Res Indian Med. 1970; 4: 152-9.

Valka I, Walterova D, Popova ME, Preininger V, Simanek V. Isolation, chemistry and biology of alkaloids from plants of Papaveraceae. Part XCIX. Separation and quantification of some alkaloids from Fumaria parviflora by capillary isotachophoresis. Planta Med. 1985; 51: 319-22.

Suau R, Cabezudo B, Rico R, Najera F, Lopez-Romero JM. Direct determination of alkaloid contents in Fumaria species by GC-MS. Phytochem Anal. 2002; 13: 363-7.

Sosek J, Guedon JD, Adam T, Bochorakova H, Taborska E, Valka I, Simanek V. Alkaloids and organic acids content of eight Fumaria species. Phytochem Anal. 1999; 10: 6-11.

Popova ME, Simanek V, Dolejs L, Smysl B, Preininger V. Isolation, chemistry and biology of alkaloids from plants of the Papaveraceae. Part LXXXV. Alkaloids from Fumaria parviflora and F. kralikii. Planta Med. 1982; 45: 120-2.

Hussain SF, Maurice S. Parviflorine, a glycosidic spirobenzylisoquinoline alkaloid. Tetrahedron Lett. 1980; 21: 1909-12.

Hilal SH, Aboutabl EA, Youssef SAH, Shalaby MA, Sokkar NM. Lipoidal matter, flavonoid content, uterine stimulant and gonadal hormone-like activities of Fumaria parviflora Lam. growing in Egypt. Plantes Medicinales et Phytotherapie. 1993; 26: 383-96.

Anonymous. The Ayurvedic Pharmacopoeia of India. Part I. Vol. I. 1st ed. Delhi: Ministry of Health and Family welfare, Department of Health, Government of India; 2001, 143.

Anonymous. Determination of ash value and extractive value. In: World Health organization, editor. Quality control methods for medicinal plant materials. 1st ed. Delhi: A.I.T.B.S. Publishers and distributors; 2002, 28-30.

Sreevidya N, Mehrotra S. Spectrophotometric method for estimation of alkaloids precipitable with dragendorff’s reagent in plant materials. J AOAC International. 2003; 86(6): 1124-7.

Kalola J, Shah M. Free radical scavenging activity of Inula cappa. Ars Pharm. 2006; 47(4): 387-8.


Refbacks

  • There are currently no refbacks.