Assesment of Antidiabetic Activity of Mangifera indica Seed Kernel Extracts in Streptozotocin Induced Diabetic Rats

Abstract

The objective of the study was to screen the extracts of Mangifera indica seed kernel for its antidiabetic activity so that tons of mango seed kernels going waste during the mango season can be utilized as house hold remedy in treating diabetes so that the dose and cost of the actual treatment can be brought down. Extracts were evaluated for their glucose reducing effect in both normal and diabetic rats at the dose of 200 mg/kg body weight. Diabetes was induced by administering streptozotocin at 65 mg/kg body weight in citrate buffer intraperitonially. Blood samples were collected through tip of tail vein and the fasting blood glucose levels were estimated by using reactive strips of glucose oxidase and peroxidase. Serum lipid profiles were carried out by using ready kits by colorimetric method. The results indicate aqueous and methanolic extract of Mangifera indica seed kernel possesses significant antidiabetic activity.