Invitro Anthelmintic Activity of Bark of Azadirachta indica against Ascardi galli and Eudrilus eugeniae


Affiliations

  • VDF School of Pharmacy, Department of Phacognosy and Phytochemistry, Latur, Maharashtara, India
  • K.L.E. Society's College of Pharmacy, Department of Pharmacognosy and Phytochemistry, Belgaum, Karnataka, 590010, India
  • RMES's College of Pharmacy, Department of Pharmaceutics, Gulbarga, Karnataka, India
  • M.B.E.S College of Pharmacy, Latur, 413531, India

Abstract

The present study was undertaken to evaluate the anthelmintic activity of aqueous and ethanolic extracts of the bark of Azadirachta indica (Family - Meliaceae) and its different extracts (viz. ethanol and aqueous) against Ascardi galli and Eudrilus eugeniae. Various concentrations (50 and 100 mg/ml) of ethanolic and aqueous extracts and its various fractions were evaluated in the bioassay involving determination of time of paralysis (P) and time of death (D) of both types of the worms. Piperazine citrate was used as standard anthelmintic drug and distilled water was used as control. The results of the present study indicated that the alcoholic ethanol and aqueous extracts of the bark significantly exhibited paralysis (P < 0.05) in worms in lower dose 50 mg/ml and also caused death of worms especially at higher concentration of 100 mg/ml, as compared to standard drug. Further studies are in process to isolate the active principle's responsible for the activity.

Keywords

Azadirachta indica Bark, Anthelmintic Activity, Ascardi galli and Eudrilus eugeniae, Piperazine Citrate.

Subject Discipline

Pharmacy and Pharmacology

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