An Institutional Study for Determining the Correlation of Oral Submucous Fibrosis with Serum Haemoglobin Level: A Retrospective Analysis of 100 Cases


  • The Oxford Dental College, Department of Oral and Maxillofacial Pathology, Bangalore, Karnataka, India


Aim: Oral submucous fibrosis (OSF) is a potentially malignant, chronic progressive disorder affecting most parts of the oral cavity with different clinical presentation depending upon the stage of the disease. It has multifactorial aetiology triggering the disease process. Aetiological factors that have been attributed are areca nut chewing, nutritional deficiencies, immunological processes and genetic predisposition. Patients with OSF show significant decrease in the level of haemoglobin causing anaemia. The aim of this study was to find for any correlation between the serum haemoglobin level and OSF.
Materials and methods: In this institutional study, 100 clinically diagnosed and histopathologically confirmed OSF patients were retrieved, of which 68 patients were included in the study along with 30 healthy controls. Serum haemoglobin levels were retrieved retrospectively from the haematological records.
Results: The study showed no significant correlation between OSF and serum haemoglobin. Serum haemoglobin in the study group and the control group did not show any significant difference.
Conclusion: There is no significant correlation between the serum haemoglobin level with OSF and also with control groups. Further large-scale prospective studies with different stages of OSF are indicated to find a correlation between the level of serum haemoglobin and OSF in this part of the country.


Oral submucous fibrosis, Serum haemoglobin, Iron deficiency anaemia

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