Clinical Efficacy of Subgingivally Delivered 0.5% Controlled Release Clarithromycin Gel in the Management of Chronic Periodontitis

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Authors

  • Ambika Arora
     Department of Periodontology, ITS Dental College, Muradnagar, Ghaziabad ,IN
  • Vidya Dodwad
     Department of Periodontology, ITS Dental College, Muradnagar, Ghaziabad ,IN
  • Shubhra Vaish
     Department of Periodontology, ITS Dental College, Muradnagar, Ghaziabad ,IN
  • Anshul Arora
     Department of Conservative Dentistry & Endodontics, ITS Dental College, Muradnagar, Ghaziabad ,IN

Keywords:

Clarithromycin, Local Drug Delivery, Periodontitis, Scaling and Root Planing
Endodontics

Abstract

Background: Main indication of adjunctive use of local antimicrobials lie around situations where the outcome of non-surgical mechanical treatment results in limited number of residual pockets. Purpose of this investigation was to evaluate clinical effect of subgingival application of 0.5% clarithromycin gel adjunctive to scaling and root planing (SRP) in management of localized chronic periodontitis.

Materials and method: Thirty sites in patients with chronic periodontitis were categorized randomly into two treatment groups: Scaling and Root Planing (SRP) plus 0.5% clarithromycin gel and SRP only. Clinical evaluation was undertaken using gingival index of Loe and Silness and plaque was assessed using the Turesky et al modification of Quigley Hein Index at baseline, 15 days and 1 month. Pocket probing depth and clinical attachment level were also measured using customized acrylic stents.

Result: Both therapies resulted in significant clinical improvements. Gingival index, probing depth and relative attachment level showed significantly better reduction in CLM group than in the control group. Plaque index also reduced in both the groups but the difference was not statistically significant between the groups.

Conclusion: Although both treatment strategies seem to benefit patients, the adjunctive use of 0.5% clarithromycin showed significant results with respect to clinical parameters.

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Published

2018-09-12

How to Cite

Arora, A., Dodwad, V., Vaish, S., & Arora, A. (2018). Clinical Efficacy of Subgingivally Delivered 0.5% Controlled Release Clarithromycin Gel in the Management of Chronic Periodontitis. Journal of Pierre Fauchard Academy (India Section), 28(2), 68–72. Retrieved from http://informaticsjournals.com/index.php/jpfa/article/view/22235

Issue

Volume 28, issue 2, June 2014

Section

Original Articles

License

All the articles published in JPFA are distributed under a creative commons license. The journal allows the author(s) to hold the copyright of their work (all usages allowed except for commercial purpose).

 

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