Actual Proliferating Index as an Indicator of Prognosis in Oral Malignancy and Premalignancy


  • Modern Dental College & Research Centre, Department of Oral and Maxillofacial Pathology & Microbiology, Indore, Madhya Pradesh, India
  • Sharad Pawar Dental College & Hospital, Department of Oral and Maxillofacial Pathology & Microbiology, Wardha, Maharashtra, India


The purpose of this study was to use actual proliferation index to examine the possible association between epithelial proliferation and disease progression in the oral mucosa. Ki-67 labeling index (LI) and argyrophilic nucleolar organizer regions(AgNORs) count per nucleus were used to draw actual proliferation index (API). The immunohistochemistry (IHC) was carried out for ki-67 by using MIB-1 clone in 30 leukoplakia, 30 oral squamous cell carcinoma (OSCC), and 10 normal oral mucosa (NOM). The AgNORs count per nucleus, ki-67 LI and API was significantly higher in OSCC followed by leukoplakia and NOM. Leukoplakia with dysplasia showed significantly higher APT as compared to leukoplakia without dysphasia. The APT is useful as a prognostic factor and also helps to determine treatment modality for patients with premalignant and malignant lesions.


Oral Squamous Cell Carcinoma, Leukoplakia, Ki-67 Labelling Index, AgNORs Count, Actual Proliferating Index

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