Anti-Arthritic Activity of Dashanga Ghana (An Ayurvedic Compound Formulation) against Freund's Adjuvant Induced Arthritis in Charles Foster Albino Rats
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Keywords:Arthritis, Ayurveda, Dashanga Ghana, Freund's Adjuvant, Paw Oedema.
AbstractIntroduction: Arthritis is the most common cause of disability, limiting the activities of adults throughout the world. Apart from the conventional treatment strategies using non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids, newer and safer drugs are continuously being searched, as long-term usage of these drugs have resulted in adverse effects. Besides this, currently a number of medicinal plants are under scientific evaluation to develop a promising remedy in these cases. There is a need to investigate the complete therapeutic potential of these herbals for providing newer and safer treatment options with minimum side effects. Considering this, a polyherbal Ayurvedic compound formulation (Dashanga Ghana) has been studied in experimental animals to evaluate anti-arthritic activity. Materials and Methods: Dashanga Ghana has been prepared in the laboratory by following standard guidelines. Charles Foster albino rats were used to evaluate the activity through Freund's adjuvant induced arthritis model. Results and Conclusions: Dashanga Ghana is found to possess significant anti-arthritic activity. Further studies are required to identify and characterize exact active phyto-constituents and to elucidate the exact mechanism of action, which is responsible for the observed pharmacological profile.
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Ruknuddin, G., Patgiri, B. J., Prajapati, P. K., Ashok, B. K., & Ravishankar, B. (2015). Anti-Arthritic Activity of <i>Dashanga Ghana</i> (An Ayurvedic Compound Formulation) against Freund’s Adjuvant Induced Arthritis in Charles Foster Albino Rats. Toxicology International, 22(1), 141–146. Retrieved from http://informaticsjournals.com/index.php/toxi/article/view/20325