Protective Effect of Ferulic Acid on Erythrocytes against Experimental Oxidative Stress Models
Various pathological conditions in thebodyare observed as a result of cellular damage. Damage to erythrocytes makes them less capable of carrying oxygen. Some therapeutic agents are known to cause lysis of erythrocytes. In the present study, ferulic acid was used to assess protective effects on erythrocytes against various hemolytic insults. Experimental models viz. hemoglobin- induced linoleic acid peroxidation, H2O2 induced hemolysis and CuOOH-induced hemolysis were used to study theprotective effect of ferulic acid. Ferulic acid demonstrated concentration-dependent inhibition in the experimental models. In all the three cases, maximum inhibition of hemolysis was observed at 250 μg/ml of ferulic acid. The study establishes ferulic acid as apotential antihemolytic agent.
Erythrocytes, Oxidative Stress, Antioxidant, Ferulic Acid.
Pharmacy and Pharmacology
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