Safety Evaluation of Nimovet® in Poultry Birds


Affiliations

  • Orissa University of Agriculture and Technology, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Bhubaneswar, India
  • Orissa University of Agriculture and Technology, Department of Veterinary, College of Veterinary Science and Animal Husbandry, Bhubaneswar, India
  • Orissa University of Agriculture and Technology, Department of Veterinary Pathology Biochemistry, College of Veterinary Science and Animal Husbandry, Bhubaneswar, India

Abstract

Nimesulide, a NSAID causes toxicity to poultry birds and indirectly to human through residue present in poultry meat. Birds of control and treated group (Gr-C, Gr-50, Gr-100 and Gr-200) received 10% ethanol, 50, 100 and 200 ppm Nimesulide (Nimovet®) in drinking water up to 42 days, respectively. Statistical analysis done by ANOVA and LSD by Turkey's test. No mortality was observed in treated groups. There was progressive and a significant reduction in feed and water intake in birds of Gr-200 at day 21, 28 and 42 as compared to control birds. The % body weight gain was significantly reduced in Gr-50&Gr-100 at 21 day and Gr-200 from 14 to 42 day interval. Urea level was significantly increased in birds of Gr-50 &100 by 1.5 fold and Gr-200 by 2 fold as compared to the birds of Gr-C. The serum ALT, AST and ALP activity was significantly increased in the birds of Gr-200 as compared to birds of Gr-C. Histo-pathological alterations were observed in heart, liver, lungs and kidney leaving brain, intestine, thymus, spleen and bursa intact in the birds of Gr-200 at 42 day interval. Cumulative administration of Nimesulide (Nimovet®) in poultry birds is (i) safe up to 100 ppm for 6 week period and (ii) unsafe with organic toxicity at 200 ppm. In consideration of the present findings it could be predicted that Nimesulide (Nimovet®) at higher dose could cause toxicity to poultry birds itself and ultimate consumers including scavenger birds and animals.

Keywords

Nimesulide, Poultry Birds, Toxicity, Safety Evaluation.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

Refbacks

  • There are currently no refbacks.