Risk Assessment of ZnO Nanoparticles Revelation on Erythrocyte Membrane


Abstract

Rapid developments in the cosmetics, food and drug applications Zinc oxide (ZnO) nano materials have resulted in concerns related to the risk of overexposure of human blood. The rationale of this study was to systematically research the influence of nano-ZnO on erythrocyte. The ZnO nanoparticle was prepared by sol-gel method with size of 40 ± 5 nm. The erythrocytes treated with nano-ZnO underwent abnormal sedimentation, aggregation along with dose dependent haemolysis. The ghost cells were investigated by using ultrathin cell section in the case under nano-ZnO. The RBC membrane destruction further confirmed by malondialdehyde (MDA) quantification. The results imply better understanding of the interaction between erythrocytes and nano-ZnO and will help in assessing the risk of nanomaterial toxicity in blood that may have potential toxicity to human being health. The following results suggest that the risk assessment of nano-materials and nano-products should be carried out prior to their wide application although they hold much more inconceivable and remarkable advantages.

Keywords

Zinc Oxide Nanoparticles, Erythrocyte, Nanotoxicity.

Subject Discipline

Pharmacy and Pharmacology

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