Toxic Evaluation of Subchronic Exposure to Cadmium, Imidacloprid, and their Combination on Hematological Parameters in Buffalo Calves


  • Guru Angad Dev Veterinary and Animal Sciences University, Department of Pharmacology and Toxicology, College of Veterinary Science, Ludhiana, India


The present investigation was undertaken to evaluate hematological alterations induced by oral subchronic exposure to cadmium, imidacloprid, and their combination in buffalo calves. Cadmium exposure produced a significant decrease in hemoglobin (Hb) concentration, Total Erythrocyte Count (TEC), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and MCH Concentration (MCHC). There was a significant increase in Total Leukocyte Count (TLC) but it did not produce any change in Erythrocyte Sedimentation Rate (ESR). Repeated oral administration of imidacloprid produced a significant decrease in Hb, PCV, TEC, MCV, MCH, and MCHC; however, there was a significant elevation in the levels of ESR and TLC. The combined exposure of cadmium and imidacloprid produced a significant decline in Hb concentration, PCV, TEC, MCV, and MCHC. It produced a significant increase in ESR and TLC, but no changes were observed in the levels of MCH.


Buffalo Calves, Cadmium, Imidacloprid, Subchronic, Toxicity.

Subject Discipline

Pharmacy and Pharmacology

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