Haematological profile of subacute oral toxicity of fluoride and ameliorative efficacy of aluminium sulphate in goats

Jump To References Section

Authors

  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K ,IN
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K ,IN
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K ,IN
  • Division of Veterinary Physiology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K ,IN
  • Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST, R.S. Pura, Jammu, J&K ,IN
  • Director, National Dairy Research Institute, Karnal, Haryana ,IN

Keywords:

Aluminium sulphate, Goats, Haematological profile, Sodium fluoride

Abstract

High affinity of the fluoride to the bone causes intoxication of bone marrow resulting into alterations in normal hematological profile. In present study sodium fluoride alone and with aluminium sulphate (ameliorative agent) was administered orally daily for 30 days in healthy goats of group 1 and 2 respectively to access the effect on the hematological profile on different days of exposure. Exposure of sodium fluoride alone produced significant reduction in hemoglobin (Hb), packed cell volume (PCV), total leucocytes count (TLC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) and increase in blood clotting time. However, values of total erythrocyte count (TEC) and differential leucocytes count (DLC) were not significantly changed. On comparing the observations of ameliorative group with the group 1 goats, it is concluded that the use of the ameliorative salt Al2(SO4)3 has beneficial effects on the alterations in values of Hb, PCV , TLC, MCV, MCH and MCHC except blood clotting time produced by the subacute exposure of sodium fluoride in goats.

Downloads

Download data is not yet available.

Published

2018-04-05

How to Cite

V., K., P. K., V., N. K., P., J., K., ., K., R., R., & A. K., S. (2018). Haematological profile of subacute oral toxicity of fluoride and ameliorative efficacy of aluminium sulphate in goats. Toxicology International, 16(1), 31–35. Retrieved from http://informaticsjournals.com/index.php/toxi/article/view/20841

Issue

Section

Original Research
Received 2018-04-05
Accepted 2018-04-05
Published 2018-04-05

 

References

Banks, RE and Goldwhite, H (1966): Fluoride chemistry. In: Smith F A (Ed) Handbook of Experimental Pharmacology, Vol. 20 Part 1, 608 New York Springer Verlag.

Behera, SK (1993): Studies on fluoride poisoning in cattle due to industrial pollution. M.V.Sc. Thesis. Submitted to Orissa University of Agriculture and Technology, Bhubaneswar.

Benzamin, MM (1985): Haematology. Outline of Veterinary Clinical Pathology. pp 60-128. Kalyani Publisher, New Delhi. Blood, DC and Radostits, OM (1989): Veterinary Medicine. 7th edn. pp.1258. ELSB/Bailliere Tindall, London.

Donald H, Bolenbaugh, DL and Convey, EM (1979): Hypothyroidism and anaemia related to fluoride in dairy cattle. J. Dairy Sci., 62: 416-23.

Gujarathi, SR, Singh Bhoop and Bhikane, AU (1991): Effect of acute experimental fluorine poisoning on hematological and biochemical indices in buffalo calves (Bubalus bubalis). Indian J. Vet. Med., 11: 80-82.

Hillman, D, Bolenbaugh, DL and Convey, EM (1979): Hypothyroidism and anaemia related to fluoride in dairy cattle. J. Dairy Sci., 62: 416-423.

Hoogstratten, B, Leone, NC, Shupe, JL, Greenwood, DA and Liberman, J (1965): Effect of fluorides on haemopoietic system, liver and thyroid gland in cattle. J. Am. Med. Assoc., 192: 26-32.

Jagadish, S, Singh, LK, Samad, A and Bhalerao, DP (1998): Bovine fluorosis I: Clinical pathology and investigation into source of fluorine. Indian Vet. J., 75: 335-337.

Majeed, S (2007): 5000 in Doda contract flourosis, lose teeth. 29 January 2007. Greater Kashmir, J&K.

Marconi, N (2000): Studies on experimental fluorosis and its amelioration in buffalo M.V.Sc. Thesis, Punjab Agricultural University, Ludhiana, India.

Mohiuddin, SM and Reddy, MV (1989): Haematological and biochemical studies on fluoride toxicity in sheep. Indian Vet. J., 66: 1089-91.

Senedecor, GW and Cochran, WJ (1989): Statistical Methods, Oxford IBH Co., Bombay. pp 61.

Singh, JL and Swarup, D (1994): Fluorosis in buffaloes. Vet Rec, 135: 260-61.

Swarup, D and Singh, YP (1989): Bovine fluorosis in a brick kiln congested zone. Indian J. Vet. Med., 9: 12-14.

Tiwary, SN, Singh, CDN, Jha, GJ and Sinha, BK (1978): Some observations on pathology of experimental fluorine poisoning in sheep. Indian J. Anim. Hlth., 142-43.

Yur, F, Belge, F, Mert, N and Yoruk, I (2003): Changes in erythrocyte parameters of fluorotic sheep. Fluoride, 36(3): 152-56.