Toxicity studies on a Unani herbal formulation “Capsule Hudar” in albino rats


Affiliations

  • University of Kashmir, Regional Research Institute of Unani Medicine, Srinagar, JK, 190 006, India
  • University of Kashmir, Department of Biochemistry, Srinagar, JK, 190 006, India
  • Central Council for Research in Unani Medicine, New Delhi, India

Abstract

Capsule Hudar, a very effective compound formulation of Unani System of Medicine, contains Azraqi (Strychnos nux vomica) a deadly poison as one of its constituents. However, it (Strychnos nux vomica) is detoxified, using a classical crude method, before its use to prepare the drug. Results on the evaluation of the drug at dose rate of 5 mg/kg body weight, orally as aqueous extract for 60 days in either sex for its toxicity in Wistar albino rats (150 ± 10g body weight) did not show any significant change in the blood glucose, blood urea and blood urea nitrogen and serum albumin and proteins levels. The activities of GOT/GPT and ACP/ALP levels in serum, brain, kidney, liver and spleen were also not significantly different when compared to controls.

Keywords

capsule hudar, detoxification, strychnine,strychnos nux vomica, Unani herbal formulation

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References

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