Therapeutic Management of Toxicity of Ficus tsjahela Leaves in Cattle


Abstract

The toxicity episodes of Ficus tsjahela leaves cattle and treatment regimen were studied. The clinical signs in Ficus tsjahela toxicity were salivation, generalized clonic and tonic seizures, nystagmus, stereotypic gnawing behavior, hyperesthesia, ataxia, paddling movements while in recumbency and stereotyped gnawing behavior or eating inanimate objects. The affected animals were treated effectively with diazepam @ 0.5 mg/kg i/v and thiamine hydrochloride @ 10 mg/kg i/m with intravenous administration of 5-10 ml/kg of 10 % dextrose solution twice at 10 to 12 h interval for 3-4 days till complete recovery. There was no change in serum concentrations of ALT, AST, BUN, creatinine, calcium, magnesium, phosphorus except acute hyperglycemia. The phytochemical analysis revealed the presence of steroids, terpenes, diterpenes, lactones, flavonoids, tannins and glycosides. The results of this study demonstrated the toxicity of Ficus tsjahela leaves in cattle and its therapeutic management with diazepam, thiamine hydrochloride and dextrose.

Keywords

Ficus tsjahela, Toxicity, Cattle, Treatment, Diazepam, Thiamine, Dextrose.

Subject Discipline

Pharmacy and Pharmacology

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