Biochemical Changes after Short-term Oral Exposure of Jatropha curcas Seeds in Wistar Rats

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Authors

  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anjora, Durg - 491001, Chhattisgarh ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anjora, Durg - 491001, Chhattisgarh ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anjora, Durg - 491001, Chhattisgarh ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anjora, Durg - 491001, Chhattisgarh ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Anjora, Durg - 491001, Chhattisgarh ,IN

Keywords:

Jatropha seed protein supplementation, phytotoxins, Wistar rats
Systems biology

Abstract

Jatropha curcas (Euphorbiaceae) is a multipurpose shrub with varied medicinal uses and is of significant economic importance. In addition to being the source of biodiesel, its seeds are also considered highly nutritious and could be exploited as a rich and economical protein supplement in animal feeds. However, the inherent phytotoxins present in the seed is the hindrance. The toxicity nature of the seeds of the local variety of J. curcas is not known. Therefore, investigations were undertaken to evaluate the short-term oral toxicity of the seeds of locally grown J. curcas . Short-term toxicity was conducted in rats by daily feeding the basal diet (Group I), and the diet in which the crude protein requirement was supplemented at 25% (Group II) and 50% (Group III) levels through Jatropha seed powder. The adverse effects of Jatropha seed protein supplementation (JSPS) were evaluated by observing alterations in biochemical profiles. The biochemical profile of rats fed on diet with JSPS at both the levels revealed significant reduction in plasma glucose and total protein and increase in plasma creatinine, transaminases (Plasma glutamic pyruvic transaminase and Plasma glutamic oxaloacetic transaminase), and alkaline phosphatase.

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Published

2018-05-16

How to Cite

Awasthy, V., Vadlamudi, V. P., Koley, K. M., Awasthy, B. K., & Singh, P. K. (2018). Biochemical Changes after Short-term Oral Exposure of <i>Jatropha curcas</i> Seeds in Wistar Rats. Toxicology International, 17(2), 67–70. Retrieved from http://informaticsjournals.com/index.php/toxi/article/view/21180

Issue

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

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