Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats

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Authors

  • Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102 ,IN
  • Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102 ,IN
  • NTR College of Veterinary Science, Gannavaram, Krishna Dt., Andhra Pradesh - 521 102 ,IN
  • Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102 ,IN
  • Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh - 521 102 ,IN

Keywords:

Atorvastatin, garlic, kidney
Mammalogy

Abstract

A total of 56 male Sprague dawley rats of uniform weight and age were randomly divided into seven groups consisting of eight rats in each group. Groups 1, 2, and 3 served as plain control, dyslipidaemic control (DL), and atorvastatin control, respectively. Groups 4, 5, 6, and 7 received 1, 0.5, 0.25, and 0.75% fresh garlic w/w in feed, respectively in addition to the high-fat and high-cholesterol diet and administered with atorvastatin orally for 12 weeks at the rate of 10, 5, 7.5, and 2.5 mg/kg b.wt., respectively. Plasma creatinine was estimated at 4-week intervals, whereas histopathology, electron microscopy, and estimation of TBARS concentration in kidney were conducted at the end of experiment. The TBARS concentration in DL was significantly (P<0.05) increased when compared with groups 1, 3, 6, and 7. On histopathological examination, kidney sections of group 3 had mild degenerative changes in the tubules with fatty change in few tubules, while groups 4 and 5 exhibited mild-tomoderate degenerative and fatty changes in tubules with inter tubular hemorrhages. The electron microscopy of group 2 showed hypertrophy of Bowman's capsule, while that of group 4 showed secretary deposits in the cytoplasm. The interaction studies on kidney indicated that high dose of atorvastatin + garlic has negative safety profile when compared with groups having low dose of statin and high dose of garlic.

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Published

2018-05-16

How to Cite

Reddy, G. D., Reddy, A. G., Rao, G. S., Haritha, C., & Jyothi, K. (2018). Interaction Study on Garlic and Atorvastatin with Reference to Nephrotoxicity in Dyslipidaemic Rats. Toxicology International, 17(2), 90–93. Retrieved from http://informaticsjournals.com/index.php/toxi/article/view/21185

Issue

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

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