Mechanisms Pertaining to Arsenic Toxicity


Affiliations

  • Guru Nanak Dev University, Department of Pharmaceutical Sciences, Amritsar, 143 005, India
  • Punjabi University, Department of Pharmaceutical Sciences and Drug Research, Patiala, 147 002, India
  • Khalsa College of Pharmacy, Department of Pharmacology, Amritsar, 143 005, India

Abstract

Arsenic is an environmental pollutant and its contamination in the drinking water is considered as a serious worldwide environmental health threat. The chronic arsenic exposure is a cause of immense health distress as it accounts for the increased risk of various disorders such as cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. In addition, the exposure to arsenic has been suggested to affect the liver function and to induce hepatotoxicity. Moreover, few studies demonstrated the induction of carcinogenicity especially cancer of the skin, bladder, and lungs after the chronic exposure to arsenic. The present review addresses diverse mechanisms involved in the pathogenesis of arsenic-induced toxicity and end-organ damage.

Keywords

Arsenic, carcinogenicity, cardiovascular dysfunction, diabetes, hepatotoxicity, nephrotoxicity, neurotoxicity

Subject Discipline

Zoology

Full Text:

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