A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs

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Authors

  • P. Shivakumar
     ,IN
  • M. Usha Rani
     ,IN
  • A. Gopala Reddy
     ,IN
  • Y. Anjaneyulu
     ,IN

Keywords:

Doxorubicin, histopathology, vitamin-E Original Article on

Abstract

In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg.

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Published

2018-08-14

How to Cite

Shivakumar, P., Rani, M. U., Reddy, A. G., & Anjaneyulu, Y. (2018). A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs. Toxicology International, 19(3), 241–244. Retrieved from http://informaticsjournals.com/index.php/toxi/article/view/21754

Issue

Volume 19, Issue 3, September - December 2012

Section

Original Research
Received 2018-08-14
Accepted 2018-08-14
Published 2018-08-14

 

References

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