Release and toxicity of dental resin composite


  • Government College of Dentistry, Department of Conservative Dentistry and Endodontics, Indore, Madhya Pradesh
  • Government College of Dentistry, Department of Conservative Dentistry and Endodontics, Indore, Madhya Pradesh, India
  • Babu Banarasi Das Dental College, Department of Periodontics, Lucknow, Uttar Pradesh, India
  • Indian Institute of Toxicological Research, Council of Scientific and Industrial Research, In‑vitro Toxicology Laboratory, New Delhi, India


Dental resin composite that are tooth‑colored materials have been considered as possible substitutes to mercury‑containing silver amalgam filling. Despite the fact that dental resin composites have improved their physico‑chemical properties, the concern for its intrinsic toxicity remains high. Some components of restorative composite resins are released in the oral environment initially during polymerization reaction and later due to degradation of the material. In vitro and in vivo studies have clearly identified that these components of restorative composite resins are toxic. But there is a large gap between the results published by research laboratories and clinical reports. The objective of this manuscript was to review the literature on release phenomenon as well as in vitro and in vivo toxicity of dental resin composite. Interpretation made from the recent data was also outlined.


Biocompatibility, dental resin composite, release phenomenon, toxicity

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