Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen Boswellia serrata

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DOI:

https://doi.org/10.18311/ti/2018/v25i4/23085

Keywords:

Adjuvant Arthritis, Antioxidants, Boswellia serrata, Oxidative Stress
Clinical Pharmacology

Abstract

A study was carried out to evaluate Boswellia serrata on adjuvant induced oxidative stress in rats. Intradermal administration of Freund's adjuvant to induce rheumatoid arthritis consequently produced oxidative damage as indicated by an increase in thiobarbituric acid reducing substances, myeloperoxidase, protein carbonyls and a reduction in superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in tissue homogenates. Oral administration of methanolic extracts ofBoswellia serrata at 500 mg/kg body weight re-established the antioxidant profile. Co-treatment with an anti-inflammatory agent, meloxicam showed an enhanced healing effect. Hence, a significant restorative effect was witnessed with the herbal adaptogen Boswellia serrata.

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Published

2019-10-22

How to Cite

Divisha, R., Rani, M. U., Kumar, B. K., & Reddy, A. G. (2019). Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen <i>Boswellia serrata</i>. Toxicology International, 25(4), 193–197. https://doi.org/10.18311/ti/2018/v25i4/23085
Received 2018-12-31
Accepted 2019-03-28
Published 2019-10-22

 

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