An Acute Toxicity Study of Tylophora Indica Leaves Extract in Wistar Rats

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Authors

  • N. S. Bembde
     ,IN
  • P. V. Meshram
     ,IN
  • P. D. Gadhave
     ,IN
  • V. M. Vaidya
     ,IN
  • S. S. Sole
     ,IN
  • R. R. Rohi
     ,IN

DOI:

https://doi.org/10.18311/ti/2018/v25i3/23751

Keywords:

Acute Toxicity, OECD Guideline 423, Tylophora indica, Wistar Rats
Pharmacology ansd Toxicology

Abstract

The present investigation was carried out to evaluate the safety of hydroalcoholic extract of Tylophora indica leaves after single dose administration to determine its potential toxicity individually as per Organisation for Economic Co-operation and Development [OECD] 423 guideline. General behaviour, adverse effects and mortality parameters were studied for up to 14 days. Extract was found safe at the oral doses of 2000 mg/kg b. wt. There were no apparent toxicity signs and death observed during experimental trial. Gross necropsy examination revealed no abnormal lesions. In view of the dose of Tylophora indica leaves consumed in traditional medicine, it is observed that there is a wide margin of safety for the therapeutic use.

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Published

2019-10-22

How to Cite

Bembde, N. S., Meshram, P. V., Gadhave, P. D., Vaidya, V. M., Sole, S. S., & Rohi, R. R. (2019). An Acute Toxicity Study of <i>Tylophora Indica<i> Leaves Extract in Wistar Rats. Toxicology International, 25(3), 163–168. https://doi.org/10.18311/ti/2018/v25i3/23751

Issue

Volume 25, Issue 3, July -September 2018

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2019-05-27
Accepted 2019-07-17
Published 2019-10-22

 

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