Manifestation of Bronchial Reactivity in Mining Workers who are Exposed to different Pollutants


  • University of Prishtina, Clinical Centre, Department of Pharmacy, Faculty of Medicine, Prishtina, Serbia
  • Hospital of Mitrovica, Department of Clinical Toxicology, Serbia
  • University of Prishtina, Clinical Centre, Department of Pharmacology, Faculty of Medicine, Serbia


In this paper the impact of air pollution on the bronchial reactivity of mine workers in Leposaviq - Kosovo with toxic metals such as: (SiO2, Pb, Zn, Particulate matter-PM) has been studied. Since body plethysmography is a highly sensitive and precise technique in the research of phenomena affecting bronchial reactivity, we have defined lung function with Body Plethysmography. Airway resistance (Raw) was recorded and Intrathoracic Gas Volume (ITGV) was measured and Specific Airway Resistance (SRaw) and specific conductance (SGaw) were calculated. The control group consisted of 35 healthy people. In our case we used histamine as a provocative test, which did not cause significant changes in bronchomotor tone (p> 0.1). In the experimental group, 59 workers of the Leposaviq - Kosovo mine were included. The results obtained from this research show that the mean Specific Resistance (SRaw), and specific conductance (SGaw) values significantly underwent changes in the experimental group compared to the control group (p <0.01). The study also found that smoking favors the adverse effects of air pollution on workers’ health. To the workers exposed to high concentrations of air pollution found change in lung function, increased bronchial reactivity, and impaired lung function at the level of gas exchange, namely a decrease in O2 partial pressure and an increase in pacific CO2 pressure in arterial blood. We also have a reduction in carbon monoxide transfer factor (p <0.01).


Leposaviq - Kosovo mine workers, Respirable noxae of SiO2, PM Ores, Pb, Zn

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Pope CA III, Dockery DW. Health effects of fine particulate air pollution: lines that connect. J Air Waste Manag Assoc. 2006; 56:709-42. 464485PMid:16805397

Osman LM, Douglas JG, Garden C, Reglitz K, Lyon J, Gordon S, Ayres JG. Indoor air quality in homes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007; 176:465-72. Available from: http:// lCode=ajrccm&resid=176/5/465 rccm.200605-589OCPMid:17507547

Halbert RJ, Isonaka S, George D, Iqbal A. Interpreting COPD prevalence estimates: What is the true burden of disease? Chest. 2003; 123:1684-92. chest.123.5.1684PMid:12740290

Pauwels RA, Rabe KF. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet. 2004; 364:613-20.

Celli BR, Mac Nee W, Agusti A. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ ERS position paper. Eur Respir J. 2004; 23:932-46. PMid:15219010

Dallas CE: Pulmotoxicity: Toxical effect on the lung. In: Williams, PL editors. Principles of Toxicology, Industrial and Environmental Application, 2nd ed. John Wilez and Sons; 2000. p. 169-87.

Pope CA III, Dockery DW. Health effects of fine particulate air pollution: Lines that connect. J Air Waste Manag Assoc. 2006; 56:709-42. 464485PMid:16805397

Montiel-Davalos A, Faro-Moreno E, Lopez-Marure R. PM2.5 and PM10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells. Inhal Toxicol. 2007; 19:91-98. Mid:17886056

Wong CM, Lam TH, Peters J, Hedley AJ, Ong SG, Tam Ayc, Liu J, Spiegelhalter DJ. Comparasion between two districts of the effects of an air pollution intervention on brochial responsiveness in primary school children in Hong Kong. J Epidemiol Community Health. 1998; 52:571-8. PMCid:PMC1756761

MRC Asthma UK. Centre in Allergic Mechanisms of Asthma. UK: Medical Research Council (MRC); 2018.

Austoker J, Linda B, editors. Historical perspectives on the role of the MRC: Essays in the history of the Medical Research Council of the United Kingdom and its predecessor, the Medical Research Committee. Oxford UP; 1989.

Hyseini K, Iljazi A, Morina N, Iljazi F, Islami H. Comparison of methylxanthines (doxofylline and diprophylline) effect in patients with bronchial hyperreactivity and bronchial asthma. RJPBCS. 2017; 5:500-09

Islami H, Veseli H, Behluli E, Morina N. Importance of the adrenergic nerve system in the response of gases in the arterial blood following the provoked bronchospasm. Medical Archives 2012; 66(5):292. PMid:23097963

Lajqi N, Ilazi A, Kastrati B, Islami H. Comparison of glucocorticoid (budesonide) and antileukotriene (montelukast) effect in patients with bronchial asthma determined with body plethysmography. Acta Informatica Medical. 2015; 23(6):347. aim.2015.23.347-351 PMid:26862243 PMCid:PMC4720827

Haxhiu MA, Islami H, Mandura I, Krasniqi A. The protective effect of Oxatomide (R 35 443) on exercise-induced asthma. Plucnebolestiituberkuloza. 1980; 32(3):122.

Haliti A, Islami P, Mustafa L, Dauti A, Bozalija A, Islami H. Effect of air pollutants on the manifestation of bronchial reactivity in a population living in proximity to a Power Plant. Toxicology International. 2018; 25(4):1-9.

Devereux G. ABC of chronic obstructive pulmonary disease. Definition, epidemiology, and risk factors, BMJ. 2006; 332:1142-1144. PMid:16690673 PMCid:PMC1459603

Shabani SH, Mustafa L, Iljazi A, Islami P, Dauti A, Islami H. Effect of glucocorticoids following application of adenosine receptor blockers in patients with chronic obstructive bronchitis and bronchial asthma. OAMJMR. 2020. (in Press).

Devereux G. ABC of chronic obstructive pulmonary disease. Definition, epidemiology and risk factors. BMC. 2006; 332:1142-4. PMid:16690673 PMCid:PMC1459603

Kaufman JD. Air pollution and mortality: Are we closer to understanding the how? Am J Respir Crit Care Med. 2007; 176:325-6. Available from: sid=176/4/325

Monn C. & Becher S. Cytotoxicity and pro inflammatory cytokines from human monocytes exposed to fine (PM2.5) and course particles (PM2.5–10) in indoor and outdoor air, Toxicology and applied pharmacology, 1999; 155: 245–252.

Samet J, Dominici F, Curriero F, Coursac I, Zeger S. Fine particulate air pollution and mortality in 20 US cities 19871994. The New Engl J of Med. 2000; 343:1742-9. PMid:11114312

Martuzzi M, Mitis F, Iavarone I, Serinelli M. Health impact of PM10 and Ozone in 13 Italian Cities. WHO2006.

Laden F, Schwartz J, Speizer F, Dockery D. Reduction in Fine Particulate Air Pollution and Mortality-extended Follow-up of the Harward Six Cities Study. Am J of Respir and Crit Care Med. 2006; 173. PMid:16424447 PMCid:PMC2662950

Morina N, Iljazi A, Iljazi F, Hyseini K, Bozalia A, Islami H. Effect of antileukotriene (Zileuton) in patients with bronchial asthma (emphasized reactors, moderate reactors, and non-reactors), RJPBCS. 2017; 8:334-42.

Morina N, Iljazi A, Iljazi F, Gashi L, Bozalija A, Rustemi F, Islami H. Effect Antileukotriene substances (Montelukast) in patients with changed bronchial reactivity (non-reactors, moderate reactors and emphasized reactors). RJPBCS. 2018; 8:1092-9.

Morina N, Haliti A, Iljazi A, Islami D, Bexheti S, Bozalija A, Islami H. Comparison of effect of leukotriene biosynthesis blockers and inhibitors of phosphodiesterase enzyme in patients with bronchial hyperreactivity. Maced J Med Sci. 2018; 187:1-5. PMid:29875845 PMCid:PMC5985875

Tornqvist H, Mills NL, Gonzalez M, Miller MR, Robinson SD, Megson IL, Macnee W, Donaldson K, Soderberg S, Newby DE, et al. Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am J Respi Crit Care Med. 2007; 176:395-400. Available from: lCode=ajrccm&resid=176/4/395 rccm.200606-872OC PMid:17446340


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