Effect of Fenugreek against Induced Sub Acute Thiacloprid Toxicity in Rats

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Authors

  • Abhisek Choudhary
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan ,IN
  • Shweta Anand
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan ,IN
  • Sunil Boghia
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan ,IN
  • Rahul Swarnkar
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan ,IN
  • Devendra Singh
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan ,IN

DOI:

https://doi.org/10.18311/ti/2020/v27i3&4/25382

Keywords:

Fenugreek, Rats, Sub-acute Toxicity, Thiacloprid
Pesticides

Abstract

The study was carried out to investigate efficacy of fenugreek against general toxicity induced by sub acute exposure of thiacloprid in rats. Wistar rats were divided in four groups having six rats in each group. Group I served as control (corn oil administered as vehicle). Group II served as thiacloprid treated group (@ 22.5 mg/kg b.wt. orally), in Group III (experimental group) thiacloprid along with fenugreek extract (@500 mg/kg.b.wt.orally) and in case of Group IV (experimental group) fenugreek seeds extract (@500 mg/kg.b.wt.orally)were administered. The thiacloprid treated groups showed clinical signs viz lacrimation, piloerection, diarrhoea and dyspnea and significantly decreased absolute and relative body weight, higher relative liver and kidney weight, decreased relative spleen weight and altered hemo-biochemical profile. Fenugreek treatment showed improvement in absolute and relative body weight and organ weight and hemo-biochemical profile. The ethanolic extract of fenugreek has the potential to restore the general toxicity, serum biochemical and hematological parameters caused by sub-acute thiacloprid toxicity.

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Published

2022-08-12

How to Cite

Choudhary, A., Anand, S., Boghia, S., Swarnkar, R., & Singh, D. (2022). Effect of Fenugreek against Induced Sub Acute Thiacloprid Toxicity in Rats. Toxicology International, 27(3&4), 113–124. https://doi.org/10.18311/ti/2020/v27i3&4/25382

Issue

Volume 27, Issue 3&4, July-December 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-05-22
Accepted 2020-10-13
Published 2022-08-12

 

References

Ford KA, Casida JE. Chloropyridinyl neonicotinoid insecticides: Diverse molecular substituents contribute to facile metabolism in mice. Chem Res Toxicol. 2006; 19:944–51. PMid: 16841963. https://doi.org/10.1021 tx0600696

Tomizawa M, Casida JE. Neonicotinoid insecticide toxicology: Mechanisms of selective action. Annu Rev Pharmacol Toxicol. 2005; 45:247–68. PMid: 15822177. https://doi.org/10.1146/annurev. pharmtox.45.120403.095930

Zhang Y, Zhong Y, Luo Y, Kong ZM. Genotoxicity of two novel pesticides for the earthworm (Eisenia fetida). Environ Pollut. 2000; 108(2):271–8. https://doi.org/ 10.1016/S0269-7491(99)00191-8

Meghwal M, Goswami TK. A review on the functional properties, nutritional content, medicinal utilization and potential application of fenugreek. J Food Process Technol. 2012; 3:181. https://doi.org/10.4172/2157 7110.1000181

Nathiya S, Durga M, Devasena T. Therapeutic role of Trigonella foenum-graecum [Fenugreek] - A Review. Int J Pharm Sci Rev Res. 2014; 27(2).

Aydin B. Effects of thiacloprid, deltamethrin and their combination on oxidative stress in lymphoid organs, polymorphonuclear leukocytes and plasma of rats. Pestic Biochem Physiol. 2011; 100(2):165–71. https://doi.org/10.1016/j.pestbp.2011.03.006

Goyal S, Sandhu HS, Brar RS. Histopathological alterations induced after oral sub-acute thiacloprid toxicity in Gallus domesticus. Vet Archiv. 2010; 80(5):673–82.

Anand S, Ahmad AH, Lal N, Pant D. Ameliorative potential of aqueous extract of Panax ginseng against acetamiprid induced subacute toxicity in rats. J Vet Pharmaco Toxicol. 2017; 16(1):30–3.

Abdel-Daim MM, AbdEldaim MA, Hassan AG. Trigonella foenum-graecum ameliorates acrylamide induced toxicity in rats: Roles of oxidative stress, proinflammatory cytokines and DNA damage. Biochem Cell Biol. 2015; 93(3):192–8. PMid: 25607344. https:/ doi.org/10.1139/bcb-2014-0122

Timbrell JA. Biomarkers of organ toxicity. Arch Ind Hyg Toxicol. 2000; 33:295–302.

Crissman JW, Goodman DG, Hildebrandt PK, Maronpot RR, Prater DA, Riley JH. Best practice guideline. Toxicol Pathol. 2004; 32:126–31. PMid: 14713558. https://doi.org/10.1080/01926230490268756

Bhardwaj S, Srivastava MK, Kapoor U, Srivastava LP. A 90 days oral toxicity of imidacloprid in female rats: Morphological, biochemical and histopathological evaluations. Food and Chem Toxicol. 2010; 48(11):85–90. PMid: 20146932. https://doi.org/10.1016/jfct.2010.02.009

Srivastava A, Srivastava MK, Raizada RB. A ninety day toxicity and one generation reproduction study in rats exposed to allethrin based LMR. J Toxicol Sci 2006; 31:1–7. PMid: 16538039. https://doiorg/10.2131 /jts.31.1

Kaviavasan S, Anuradha CV. Fenugreek seed polyphenol protect liver from alcohol toxicity. A role on hepatic detoxification system and apoptosis dicpharmazie. An Inernational J of Pharmaceut Sci. 2007; 62(4):299–304.

Verma N, Usman K, Patel N, Jain A, Dhakre S, Swaroop A. A multicenter clinical study to determine the efficacy of a novel fenugreek seed extract in patient with type-2 diabetes. J Food and Nutri Res. 2016; 60(1):2. PMid: 27733237 PMCid: PMC5061863. https://doi org/10.3402/fnr.v60.32382

Israa S, Al-Dabbagh, Layla JM, Al-Bahadyli. Study the behavioral changes and gravimetric changes for weight organs in liver, kidney and spleen exposure to insecticide imidacloprid in the white mice. World J of Pharmaceut Res. 2015; 4:114–22.

Gatne MM, Ramesh, Bhoir PS, Deore MD. Immunotoxicity studies of imidacloprid in rats. Toxicol International. 2006; 13:89–92.

Choudhary D, Chandra D, Choudhary S, Kale RK. Modulation of glyoxalase glutathione-S- transferase and antioxidant enzymes in liver, spleen and erythrocytes of mice by dietary administration of fenugreek seeds. Food Chem Toxicol. 2001; 39(10):989–97. https://doi.org/10.1016/S0278-6915(01)00040-0

Hendawi MY, Alam RTM, Abdellatief SA. Ameliorative effect of flaxseed oil against thiacloprid-induced toxicity in rats: Hematological, biochemical and histopathological study. Environ Sci Pollut Res. 2016; 23(12):11855–63. PMid: 26957428. https://doiorg/ 10.1007/s11356-016-6376-z

Azza M, El-wakf, Hanna A, Hassan AZ, Mahmoud, Marwa NH. Fenugreek potent activity against nitrate -induced diabetes in young and adult male rats Cytotechnol. 2015; 67(3):437–47. PMid: 24615531 PMCid: PMC4371570. https://doi.org/10.1007/s10616 014-9702-7

Suresh M, Mallikarjuna RN, Sharan B, Singh M, Hari Krishna B, Shravya KG. Hematological changes in chronic renal failure. Int J Sci Res Publ. 2012; 2:1–4.

Kaur B. Evaluation of toxic impacts of imidacloprid insecticide in crossbred cow calves. [Dissertation] Ludhiana: Punjab Agricultural University; 2005.

Singla S, Sandhu HS. Alteration in hematological profile of experimentally induced subchronic thiacloprid toxicosis in Gallus Domesticus. Toxicol International. 2016; 22(1):147–51. PMid: 26862276 PMCid: PMC4721163. https://doi.org/10.4103/0971 6580.172281

Singh AP, Singh A, Pandey R, Sushma. Effect of dietary supplementation of fenugreek (Trigonella foenum-graecum) leaves powder on hematology broilers chick. World J of Pharmaceut Res. 2015; 5(1):1615–21.