In vivo Acute Toxicity and Anti-inflammatory Activity of Ferula sulcata Desf. from Setif, Algeria

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Authors

  • Malika Rahmouni
     Department of Biology and Vegetal Ecology, Laboratory of Valorization of Natural and Biological Resources, Faculty of Nature and Life Sciences, University Ferhat Abbas, Sétif 19000 ,DZ
  • Meriem Hamoudi
     Department of Biology and Animals Physiology, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Natural Sciences and Life Sciences, University of Ferhat Abbas, Setif 1, Setif 19000 ,DZ
  • Randa Mlik
     National Institute of Agronomic Research of Algeria, Station of Adrar, Adrar ,DZ
  • Hocine Laouer
     Department of Biology and Animals Physiology, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Natural Sciences and Life Sciences, University of Ferhat Abbas, Setif 1, Setif 19000 ,DZ
  • Seddik Khennouf
     Department of Biology and Animals Physiology, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Natural Sciences and Life Sciences, University of Ferhat Abbas, Setif 1, Setif 19000 ,DZ
  • Saliha Dahamna
     Department of Biology and Animals Physiology, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Natural Sciences and Life Sciences, University of Ferhat Abbas, Setif 1, Setif 19000 ,DZ
  • Nour Elhouda Mekhadmi
     Department of Biology, Laboratory of Biodiversity and Applications of Biotechnology in the Agriculture Field, University of Chahid Hama Lakhdar, El-Oued ,DZ
  • Aicha Mouane
     Department of Biology, Laboratory of Biodiversity and Applications of Biotechnology in the Agriculture Field, University of Chahid Hama Lakhdar, El-Oued ,DZ

DOI:

https://doi.org/10.18311/ti/2023/v30i3/33434

Keywords:

Acute Toxicity, Anti-Inflammatory Activity, Essential oil, Ferula sulcata

Abstract

Several works are interested in studying the undesirable therapeutic effects of medicinal plants, which must be used with great caution because they can be toxic. Under this objective falls our work, which consists in studying the acute toxicity and anti-inflammatory action in vivo of the Essential Oil (EO) of the aerial part (seed) of Ferula sulcata Desf. harvested from the region of Setif in western Algeria. Two doses were applied by oral gavage (2000 and 5000 mg/kg body weight). After administration of the oil, the mice were continuously monitored for 14 days. The results obtained showed that there was no mortality or morbidity whereas the animals showed toxic effects e.g., behavioral and morphological changes. On the other hand, a significant increase (p<0.05) in body weight was observed. In addition, an important increase was recorded in the relative organ weights compared to the controls, whereas the liver was significantly increased (**p<0.05): 6.12±0.19; 6.14±0.31 in females compared to controls. Furthermore, ALT value decreased significantly (**p<0.05): 6.83±2.59 in males. In addition, the oral administration of EO at the dose of 600 mg/kg showed an interesting antiinflammatory activity comparable to indomethacin. Histopathological damage was observed in the liver and kidney tissues of mice treated with EO of this plant. Hence, the acute toxicity and anti-inflammatory activities of EO of F. sulcata Desf. are considered the first data.

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Published

2023-09-20

How to Cite

Rahmouni, M., Hamoudi, M., Mlik, R., Laouer, H., Khennouf, S., Dahamna, S., Mekhadmi, N. E., & Mouane, A. (2023). <i>In vivo</i> Acute Toxicity and Anti-inflammatory Activity of <i>Ferula sulcata</i> Desf. from Setif, Algeria. Toxicology International, 30(3), 409–418. https://doi.org/10.18311/ti/2023/v30i3/33434

Issue

Volume 30, Issue 3, July-September 2023

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2023-03-30
Accepted 2023-05-30
Published 2023-09-20

 

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