Detection of Ethanol and Methanol in Hand Sanitizers used in Public Places in Delhi during the COVID-19 Pandemic

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Authors

  • Neha Afaria
     Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN
  • Rohit Kanojia
     Department of Chemistry, University of Delhi, Delhi - 110007 ,IN
  • A. K. Jaiswal
     Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN
  • Sudhir K. Gupta
     Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN
  • T. Millo
     Department of Forensic Medicine and Toxicology, All India Institute of Medical Sciences, New Delhi - 110029 ,IN

DOI:

https://doi.org/10.18311/ti/2024/v31i2/36349

Keywords:

Adulteration, COVID-19, GC-HS, Hand Sanitizer, Methanol

Abstract

Since the COVID-19 (coronavirus disease of 2019) pandemic, alcohol-based hand sanitizers are being used widely to prevent the transmission of corona virus. But a major concern is the adulteration of methanol in hand sanitizer. Cases of methanol poisoning increased drastically during the pandemic. This study was carried out to detect ethanol and methanol in hand sanitizers that are being sold and used in public places. The hand sanitizer samples for this study were collected from different public places in Delhi from June-August 2022. A total of 53 samples were collected and the samples were run on Gas Chromatography (GC-HS) for analysis of ethanol and methanol. Methanol was detected in 25 samples. During the COVID-19 pandemic, various cases of methanol poisoning due to consumption or chronic absorption of hand sanitizer have been reported all over the world. Methanol is a toxic alcohol and long-term dermal exposure to this toxic substance can cause severe health effects. During the pandemic, the increased demand of hand sanitizer resulted in uncontrolled manufacturing and sale of hand sanitizers. Data obtained from this study highlight the need to monitor the manufacturing and sale of alcoholbased hand sanitizer by the regulatory bodies and to raise awareness among the public about the toxic effects of methanol.

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Published

2024-04-17

How to Cite

Afaria, N., Kanojia, R., Jaiswal, A. K., Gupta, S. K., & Millo, T. (2024). Detection of Ethanol and Methanol in Hand Sanitizers used in Public Places in Delhi during the COVID-19 Pandemic. Toxicology International, 31(2), 257–264. https://doi.org/10.18311/ti/2024/v31i2/36349

Issue

Volume 31, Issue 2, April-June 2024

Section

Articles

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Copyright (c) 2024 Neha Afaria, Rohit Kanojia, A. K. Jaiswal, Sudhir K. Gupta, T. Millo

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2024-01-24
Accepted 2024-03-20
Published 2024-04-17

 

References

Güntner AT, Magro L, van den Broek J, Pratsinis SE. Detecting methanol in hand sanitizers. Iscience. 2021; 24(2):102050. https://doi.org/10.1016/j.isci.2021.102050 DOI: https://doi.org/10.1016/j.isci.2021.102050

Arasteh P, Pakfetrat M, Roozbeh J. A surge in methanol poisoning amid COVID-19 pandemic: Why is this occurring? Am J Med Sci. 2020; 360(2):201. https://doi. org/10.1016/j.amjms.2020.05.019 DOI: https://doi.org/10.1016/j.amjms.2020.05.019

Mousavi-Roknabadi RS, Arzhangzadeh M, Safaei- Firouzabadi H, Mousavi-Roknabadi RS, Sharifi M, Fathi N, Jelyani NZ, Mokdad M. Methanol poisoning during COVID- 19 pandemic; A systematic scoping review. Am J Emerg Med. 2022; 52:69-84. https://doi.org/10.1016/j.ajem.2021.11.026 DOI: https://doi.org/10.1016/j.ajem.2021.11.026

Dear K, Grayson L, Nixon R. Potential methanol toxicity and the importance of using a standardised alcoholbased hand rub formulation in the era of COVID-19. Antimicrob Resist Infect Control. 2020; 9(1):1-3. https:// doi.org/10.1186/s13756-020-00788-5 DOI: https://doi.org/10.1186/s13756-020-00788-5

Jairoun AA, Al-Hemyari SS, Shahwan M. The pandemic of COVID-19 and its implications for the purity and authenticity of alcohol-based hand sanitizers: The health risks associated with falsified sanitizers and recommendations for regulatory and public health bodies. Res Social Adm Pharm. 2021; 17(1):2050-1. https://doi.org/10.1016/j.sapharm.2020.04.014

Overbeek DL, Watson CJ, Castañeda NR, Ganetsky M. A geographically distinct case of fatal methanol toxicity from ingestion of a contaminated hand sanitizer product during the COVID-19 pandemic. J Med Toxicol. 2021; 17(2):218- 21. https://doi.org/10.1007/s13181-021-00824-9 DOI: https://doi.org/10.1007/s13181-021-00824-9

https://www.fda.gov/drugs/drug-safety-and-availability/ fda-updates-hand-sanitizers consumers-should-not-use

Iranpour P, Firoozi H, Haseli S. Methanol poisoning emerging as the result of COVID-19 outbreak, radiologic perspective. Acad Radiol. 2020; 27(5):755-6. https://doi. org/10.1016/j.acra.2020.03.029 DOI: https://doi.org/10.1016/j.acra.2020.03.029

Mahdavi SA, Kolahi AA, Akhgari M, Gheshlaghi F, Gholami N, Moshiri M, Mohtasham N, Ebrahimi S, Ziaeefar P, McDonald R, Tas B. COVID‐19 pandemic and methanol poisoning outbreak in Iranian children and adolescents: A data linkage study. Alcohol Clin Exp Res. 2021; 45(9):1853- 63. https://doi.org/10.1111/acer.14680 DOI: https://doi.org/10.1111/acer.14680

Khadse PA, Murthy P. Accidental deaths from hand sanitizer consumption among persons with alcohol dependence during the COVID-19 lockdown in India: Analysis of media reports. Asian J Psychiatr. 2021; 63:102794. https:// doi.org/10.1016/j.ajp.2021.102794 DOI: https://doi.org/10.1016/j.ajp.2021.102794

Nekoukar Z, Zakariaei Z, Taghizadeh F, Musavi F, Banimostafavi ES, Sharifpour A, Ghuchi NE, Fakhar M, Tabaripour R, Safanavaei S. Methanol poisoning as a new world challenge: A review. Ann Med Surg. 2021; 66:102445. https://doi.org/10.1016/j.amsu.2021.102445 DOI: https://doi.org/10.1016/j.amsu.2021.102445

Moon CS. Estimations of the lethal and exposure doses for representative methanol symptoms in humans. Ann Occup Environ Med. 2017; 29:1-6. https://doi.org/10.1186/ s40557-017-0197-5 DOI: https://doi.org/10.1186/s40557-017-0197-5

Berkkan A, Ulutaş OK. Analytical performance and validation of Head Space-Gas Chromatography-Flame İonization Detector (HS-GC-FID) method for alcohol content and evaluation of efficiency and possible toxicity of hand sanitizers at the time of pandemic. Rev Roum Chim. 2021; 66(6):547-56.

Timothy JT, Purdy SK, Shen J, Nelson FB, Mustafa R, Wiens DJ, Reaney MJ. Toxicology of alcohol-based hand rubs formulated with technical-grade ethanol. Toxicol Rep. 2021; 8:785-92. https://doi.org/10.1016/j.toxrep.2021.03.034 DOI: https://doi.org/10.1016/j.toxrep.2021.03.034

Mihretu LD, Gebru AG, Mekonnen KN, Asgedom AG, Desta YH. Determination of ethanol in blood using Headspace Gas Chromatography with Flame Ionization Detector (HS-GC-FID): Validation of a method. Cogent Chem. 2020; 6(1):1760187. https://doi.org/10.1080/233120 09.2020.1760187 DOI: https://doi.org/10.1080/23312009.2020.1760187

Rafizadeh A, Kolahi AA, Shariati S, Zamani N, Roberts DM, Hassanian-Moghaddam H. The danger of the toxicity and inefficacy of alcohol-based hand rubs in Iran during COVID- 19: A cross-sectional study. Antimicrob Resist Infect Control. 2023; 12(1):1-7. https://doi.org/10.1186/s13756-023-01244-w DOI: https://doi.org/10.1186/s13756-023-01244-w

Abuga K, Nyamwey N, King’ondu O. Quality of alcohol-based hand sanitizers marketed in the Nairobi metropolitan area. J Pharm Sci. 2021; 24(1):29-37. https:// doi.org/10.20944/preprints202109.0427.v1 DOI: https://doi.org/10.20944/preprints202109.0427.v1

Seth S. Review of Forensic Medicine. Peepee Publishers and Distribution; 2018.

Pressman P, Clemens R, Sahu S, Hayes AW. A review of methanol poisoning: A crisis beyond ocular toxicology. Cutan Ocu Toxicol. 2020; 39(3):173-9. https://doi.org/10.1 080/15569527.2020.1768402 DOI: https://doi.org/10.1080/15569527.2020.1768402

Aggarwal S, Vijayakumar S, Singh R, Koner BC, Saijpaul R, Kumar N, Kumar A, Mittal T. Pitfalls of sanitizer use in the COVID-19 Era: A case report of hand sanitizer-induced blindness due to contamination by methanol. MAMC J Med Sci. 2022; 8(3):278.

Jang M, Yang H, Shin G, Koo JM, Hwang SY, Park J, X Oh D. Determination of methanol in commercialized alcoholbased hand sanitizing and other similar products using headspace GC-MS. Curr Anal Chem. 2022; 18(7):774-80. https://doi.org/10.2174/1573411018666220107145321 DOI: https://doi.org/10.2174/1573411018666220107145321

Holzman SD, Larsen J, Kaur R, Smelski G, Dudley S, Shirazi FM. Death by hand sanitizer: Syndemic methanol poisoning in the age of COVID-19. Clin Toxicol. 2021; 59(11):1009-14. https://doi.org/10.1080/15563650.2021.18 95202 DOI: https://doi.org/10.1080/15563650.2021.1895202

Yip L, Bixler D, Brooks DE, Clarke KR, Datta SD, Dudley Jr S, Komatsu KK, Lind JN, Mayette A, Melgar M, Pindyck T. Serious adverse health events, including death, associated with ingesting alcohol-based hand sanitizers containing methanol- Arizona and New Mexico, May-June 2020. Morb Mortal Wkly Rep. 2020; 69(32):1070. https://doi. org/10.15585/mmwr.mm6932e1 DOI: https://doi.org/10.15585/mmwr.mm6932e1

Chan AP, Chan TY. Methanol as an unlisted ingredient in supposedly alcohol-based hand rub can pose serious health risk. Int J Environ Health Res. 2018; 15(7):1440. https://doi. org/10.3390/ijerph15071440 DOI: https://doi.org/10.3390/ijerph15071440

Kweon H, Choi JW, Yoon SY. Analysis of consumer exposure cases for alcohol-based disinfectant and hand sanitizer use against coronavirus disease 2019 (covid-19). Int J Environ Health Res. 2021; 19(1):100. https://doi.org/10.3390/ ijerph19010100 DOI: https://doi.org/10.3390/ijerph19010100

Matatiele P, Southon B, Dabula B, Marageni T, Poongavanum P, Kgarebe B. Monitoring quality of alcohol-based hand sanitizers used in Johannesburg area during the Covid‐19 pandemic. 2021. https://doi.org/10.21203/rs.3.rs-612413/v1 DOI: https://doi.org/10.21203/rs.3.rs-612413/v1

Butt MH, Ahmad A, Misbah S, Mallhi TH, Khan YH, Muhammad K, Iqbal Z. Ensuring the quality and appropriate use of hand sanitizers during the COVID-19 pandemic: Suggestions and recommendations with the role of the pharmacist. Disaster Med Public Health Prep. 2022; 16(5):1708-9. https://doi.org/10.1017/dmp.2021.55 DOI: https://doi.org/10.1017/dmp.2021.55

Jairoun AA, Al-Hemyari SS, Shahwan M. The pandemic of COVID-19 and its implications for the purity and authenticity of alcohol-based hand sanitizers: The health risks associated with falsified sanitizers and recommendations for regulatory and public health bodies. Res Social Adm Pharm. 2021; 17(1):2050-1. https://doi.org/10.1016/j.sapharm.2020.04.014 DOI: https://doi.org/10.1016/j.sapharm.2020.04.014