Detection of Schizophrenia at the Onset from EEG Signal - A Machine Learning Based Approach

Jump To References Section

Authors

  • Narasinha Dutt College (Calcutta University) ,IN
  • Narasinha Dutt College (Calcutta University) ,IN

DOI:

https://doi.org/10.24906/isc/2023/v37/i1/222807

Keywords:

Electroencephalography (EEG), Random Forest, Schizophrenia, G-mean, Wilcoxon Signed Rank Test, Kendell’s Coefficient.

Abstract

The first signs of schizophrenia are thought to manifest during late adolescence. Hence, if the diagnosis can be made during the onset, then the patient can lead a comparatively functional life. The most cost-effective way to monitor the brain activity is using electroencephalography (EEG). Since the visual analysis of EEG comes with interpretation issues, researches are being carried out for machine learning based interpretation system. The authors proposed classification models using several machine learning algorithms to distinguish between normal and schizophrenic subjects from EEG data taken during the resting phase. The best result was by Random Forest (RF) with precision, sensitivity, and specificity of 0.965, 0.965, and 0.95 respectively.

Downloads

Download data is not yet available.

Published

2023-08-09

How to Cite

Sarkar, A., & Saurav Mallik, S. (2023). Detection of Schizophrenia at the Onset from EEG Signal - A Machine Learning Based Approach. Indian Science Cruiser, 37(1), 49–58. https://doi.org/10.24906/isc/2023/v37/i1/222807

Issue

Section

Feature Article

 

References

T N Laursen, M Nordentoft and P B Mortensen, Excess early mortality in schizophrenia., Annual Review of Clinical Psychology, Vol. 10, p. 425-438, 2014.

S H Sullivan, The onset of schizophrenia, Am J Psychiatry., Vol. 6, p. 105–134, 1927.

D E Cameron, Early diagnosis of schizophrenia by the general practitioner, N Engl J Med., Vol. 218, p. 221–224, 1938.

J P Docherty, D P van Kammen, S G Siris and et. al., Stages of onset of schizophrenic psychosis, Am J Psychiatry, Vol. 135, p. 420–426, 1978.

M Shim and et. al., Machine-learning-based diagnosis of schizophrenia using combined sensor-level and source-level EEG features, Schizophrenia Research, Vol. 176, No. 2-3, p. 314-319, 2016.

Y Li and et. al., Abnormal EEG complexity in patients with schizophrenia and depression, Clin. Neurophysiol, Vol. 119, No. 6, p. 1232-1241, 2018.

A Subudhi and et. al., Automated approach for detection of ischemic stroke using Delaunay Triangulation in brain MRI images, Computers in Biology and Medicine, Vol. 103, p. 116-129, 2018.

U R Acharya and et. al., Characterization of focal EEG signals: A review, Future Generation Computer Systems, Vol. 91, p. 290-299, 2019.

N R Swerdlow and et. al., https://health.ucsd.edu/news/releases/pages/2014-10-29-eeg-to-understand-treat-schizophrenia.aspx, 29 10 2014. [Online]. Available: https://health.ucsd.edu/. [Accessed 12 08 2021].

S L Oh and et. al., Deep Convolutional Neural Network Model for Automated Diagnosis of Schizophrenia Using EEG Signals, Appl. Sci, Vol. 19, No. 14, p. 1-13, 2019.

W Mumtaz, S Rasheed and A Irfan, Review of challenges associated with the EEG artifact removal methods, Biomedical Signal Processing and Control, Vol. 68, p. 2-13, 2021.

N T Doan and et. al., Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders, NeuroImage: Clinical, Vol. 15, p. 719–731, 2017.

R Chin and et. al., Recognition of schizophrenia with regularized support vector machine and sequential region of interest selection using structural magnetic resonance imaging, Scientific Reports, Vol. 8, No. 1, p. 635 - 644, 2018.

A H Neuhaus and et. al., Single-subject classification of schizophrenia by event-related potentials during selective attention, NeuroImage, Vol. 55, No. 2, p. 514–521, 2011.

C M A Chen and et. al., Machine learning identification of EEG features predicting working memory performance in schizophrenia and healthy adults, Neuropsychiatr Electrophysiol, Vol. 2, No. 1, p. 1–21, 2016.

L Santos-Mayo, L M San-José-Revuelta and J I Arribas, A computer-aided diagnosis system with EEG based on the P3b wave during an auditory odd-ball task in schizophrenia, IEEE Trans Biomed Eng, Vol. 64, No. 2, p. 395–407, 2017.

R Boostani, K Sadatnejad and M Sabeti, An efficient classifier to diagnose of schizophrenia based on EEG signals, Expert Syst App, Vol. 36, No. 3, p. 6492-6499, 2009.

A Khodayari-Rostamabad and et. al., Diagnosis of Psychiatric Disorders Using EEG Data and Employing a Statistical Decision Model, in In Proceedings of the 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, Buenos Aires, 2010.

M Sabeti and et. al., A new approach for EEG signal classification of schizophrenic and control participants, Expert Syst. Appl, Vol. 38, p. 2063–2071, 2011.

B Thilakvathi and et. al., EEG Signal Complexity Analysis for Schizophrenia during Rest and Mental Activity, Biomed. Res, Vol. 28, p. 1-9, 2017.

H Liu and et. al., A Data Driven Approach for Resting-state EEG signal Classification of Schizophrenia with Control Participants Using Random Matrix Theory, arXiv: Signal Processing, p. 1-10, 2017.

V Jahmunah and et. al., Automated Detection of Schizophrenia Using Nonlinear Signal Processing Methods, Artif. Intell. Med, Vol. 100, p. 101698, 2019. 23. R Buettner and et. al., Development of a Machine Learning Based Algorithm To Accurately Detect Schizophrenia based on One-minute EEG Recordings, in Proceedings of the 53rd Hawaii International Conference on System Sciences, Hawai, 2020.

S Racz and et. al., Multifractal and Entropy-Based Analysis of Delta Band Neural Activity Reveals Altered Functional Connectivity Dynamics in Schizophrenia, Front. Syst. Neurosci, Vol. 14, No. 49, p. 1-22, 2020.

A Goshvarpour, Schizophrenia diagnosis using innovative EEG feature-level fusion schemes, Phys. Eng. Sci. Med, Vol. 43, p. 227–238, 2020.

C R Phang and et. al., Classification of EEG-Based Brain Connectivity Networks in Schizophrenia Using a Multi-Domain Connectome Convolutional Neural Network, IEEE Journal of Biomedical and Health Informatics, Vol. 24, No. 5, p. 1333-1343, 2020.

N N Gorbachevskaya, http://brain.bio.msu.ru/eeg_schizophrenia.htm, 12 07 2019. [Online]. Available: http://brain.bio.msu.ru/. [Accessed 01 08 2021].

G Liang and C Zhang, Empirical Study of Bagging Predictors on Medical Data, in Proceedings of the 9-th Australasian Data Mining Conference (AusDM’11), Ballarat, Australia, 2011.

E A de Melo Gomes Soares and et. al., Analysis of the Fuzzy Unordered Rule Induction Algorithm as a Method for Classification, in Quinto Congresso Brasileiro de Sistemas Fuzzy, Brasil, 2018.

T Bikku, Multi-layered deep learning perceptron approach for health risk prediction, J Big Data, Vol. 7, No. 50, p. 1-7, 2020. 31. W Zhang, A Comparative Study of Ensemble Learning Approaches in the Classification of Breast Cancer Metastasis, in Proceedings of Bioinformatics, Systems Biology and Intelligent Computing, 2009. IJCBS ‘09, NW Washington, 2009.

D A Davis and et. al., Predicting individual disease risk based on medical history, in Proceeding of the 17th ACM conference on Information and knowledge management, Napa Valley, California, 2008. 33. M Khalilia, S Chakraborty and M Popescu, Predicting disease risks from highly imbalanced data using random forest, BMC Med Inform Decis. Mak., Vol. 11, No. 51, p. 1-10, 2011.

G S Suri, G Kaur and S Moein, Machine learning in detecting schizophrenia: an overview, Intelligent Automation & Soft Computing, Vol. 27, No. 3, p. 723–735, 2021.

J Laton, In search of biomarkers using electroencephalograph, in PRNI Proceedings, Tubingen, 2014.

F Li and et. al., Differentiation of Schizophrenia by Combining the Spatial Brain Network Patterns of Rest and Task P300, IEEE T Neur Sys Reh, Vol. 27, No. 4, p. 594-602, 2019.

S Zhang, Q Shini and W Wang, Classification of schizophrenia’s EEG based on high order pattern discovery, in IEEE International Conference on Bio-Inspired Computing: Theories and Applications, BICTA, Proceedings, Changsha , 2010.

A Sarkar, S S Mallik and K Roy, A Survey of Machine Learning Based Methods for the Diagnosis of Mental Health in Asia-Pacific Journal of Management and Technology (AJMT), Vol. 3, No. 2, p. 39-55, 2022.