Alteration in Antioxidant Biomolecules after the Exposure to Fluoride in Fresh Water Fish Heteropneustes fossilis


  • Department of Zoology, Aquatic Toxicology Research Laboratory, University of Lucknow, Lucknow, UP, 226007, India


Fluoride contamination in aquatic ecosystem has been recognized as one of the major problems worldwide and it is imposing a serious threat to aquatic organisms. It induces adverse physiological and biochemical effect in animals. The present study has been planned to observe toxic effect of Sodium fluoride on antioxidative biomarkers like LPO, SOD, and GSH in a fresh water catfish Heteropneustes fossilis. Fish were exposed to two sub lethal concentrations of Sodium fluoride for 30 days. After exposure, fish were sacrificed for collection of tissues for biochemical assay. It was found that SOD, GSH decreased significantly while LPO increased significantly in treated fish as compared to control. Results indicate concentration dependent induction of oxidative stress and subsequent alternations in the activities of non enzymatic and enzymatic antioxidants like LPO, GSH and SOD.


Antioxidants, Fluoride, GSH, LPO, SOD

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