A Comprehensive Review on Role of Nutrition in Management of Breast Cancer


  • Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore - 641 043, Tamil Nadu
  • Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore - 641 043, Tamil Nadu




Breast cancer, lifestyle, diet, nutrigenomics, personalized medicine


Breast cancer (BC) is the most frequent malignancy in women and the second most common cause of cancer worldwide. There’s a lot of evidence that lifestyle factors including food, body weight, and physical activity are linked to a higher risk of breast cancer. Several bioactive food ingredients, including both essential and non-essential nutrients, can change gene expression profiles. Consequently, nutrigenomics provides information on the effects of consumed nutrients and other food components on gene regulation and transcription factors, i.e., diet-gene interaction, to find dietetic components that are beneficial or damaging to one’s health. Biological processes such as epigenetics, transcriptomics, and proteomics influence nutritional genomics (nutrigenomics), which is the junction of health, food, and genomics. As a result, it will help to determine unique nutritional requirements based on a person’s genetic composition (personalized diet), and also the link between diet and chronic diseases such as cancer, opening up new avenues for a better understanding of the impacts of breast cancer and its management. Chemotherapy or radiotherapy patients with BC experience a variety of symptoms that influence their quality of life. According to research studies on nutritional therapy during BC treatment, nutritional counseling and supplementation with certain dietary elements may be useful in reducing drug-induced side effects and increasing therapeutic efficacy. As a result, nutritional control in BC patients may be considered a critical component of a multimodal treatment strategy. The goal of this review is to give a summary of the existing research on the association between dietary variables and BC.


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Trayes, K.P. and Cokenakes, S.E. Breast cancer treatment. Am. Fam. Physician., 2021, 104, 171-178.

Lisevick, A., Cartmel, B., Harrigan, M., Li, F., Sanft, T., Fogarasi, M., Irwin, M.L. and Ferrucci, L.M. Effect of the lifestyle, exercise, and nutrition (LEAN) study on long-term weight loss maintenance in women with breast cancer. Nutr., 2021, 13, 3265. doi: 10.3390/nu13093265. DOI: https://doi.org/10.3390/nu13093265

Di Meglio, A., Gbenou, A.S., Martin, E., Pistilli, B., Ligibel, J.A., Crane, T.E., Flaysakier, J.D., Minvielle, E., Vanlemmens, L., Guenancia, C. and Rigal, O. Unhealthy behaviors after breast cancer: Capitalizing on a teachable moment to promote lifestyle improvements. Cancer, 2021, 127, 2774-2787. doi: 10.1002/cncr.33565. DOI: https://doi.org/10.1002/cncr.33565

Augimeri, G., Montalto, F.I., Giordano, C., Barone, I., Lanzino, M., Catalano, S., Andò, S., De Amicis, F. and Bonofiglio, D. Nutraceuticals in the Mediterranean diet: potential avenues for breast cancer treatment. Nutr., 2021, 13, 2557. doi: 10.3390/nu13082557.

Lorenzo, P.M. and Crujeiras, A.B. Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks. Fd. Funct., 2021, 12, 1402-1414. doi: 10.1039/d0fo01984d. DOI: https://doi.org/10.1039/D0FO01984D

Ubago-Guisado, E., Rodríguez-Barranco, M., Ching-López, A., Petrova, D., Molina- Montes, E., Amiano, P., Barricarte-Gurrea, A., Chirlaque, M.D., Agudo. A. and Sánchez, M.J. Evidence update on the relationship between diet and the most common cancers from the European prospective investigation into cancer and nutrition (EPIC) study: A systematic review. Nutr., 2021, 13, 3582. doi: 10.3390/nu13103582. DOI: https://doi.org/10.3390/nu13103582

Bhattacharya, T., Dutta, S., Akter, R., Rahman, M., Karthika, C., Nagaswarupa, H.P., Murthy, H.C., Fratila, O., Brata, R. and Bungau, S. Role of phytonutrients in nutrigenetics and nutrigenomic perspective in curing breast cancer. Biomol., 2021, 11, 1176. doi: 10.3390/biom11081176. DOI: https://doi.org/10.3390/biom11081176

Ray, S.K. and Mukherjee, S. Nutrigenomics and lifestyle facet- A modulatory molecular evidence in progression of breast and colon cancer with emerging importance. Curr. Mol. Med., 2021, 22, 336-348. doi: 10.2174/1566524021666210331151323. DOI: https://doi.org/10.2174/1566524021666210331151323

Nair, C.V., Suresh, A., Navaneetha, S. and Roshni, P.R. Diet and breast cancer: A review on prolon fast mimicking diet in the treatment of breast cancer. Ann. Romanian Soc. Cell Biol., 2021, 25, 17666-17673.

Romanos-Nanclares, A., Gea, A., Martínez-González M.Á., Zazpe, I., Gardeazabal, I., Fernandez-Lazaro, C.I. and Toledo, E. Carbohydrate quality index and breast cancer risk in a Mediterranean cohort: The SUN project. Clin. Nutr., 2021, 40, 137-145. doi: 10.1016/j.clnu.2020.04.037. DOI: https://doi.org/10.1016/j.clnu.2020.04.037

Omofuma, O.O., Steck, S.E., Olshan, A.F. and Troester, M.A. The association between meat and fish intake by preparation methods and breast cancer in the Carolina Breast Cancer Study (CBCS). Breast Cancer Res. Treat., 2022, 11, 1-5. doi: 10.1007/s10549-022-06555-x. DOI: https://doi.org/10.1007/s10549-022-06555-x

Sasanfar, B., Toorang, F., Zendehdel, K. and Salehi-Abargouei, A. Substitution of dietary macronutrients and their sources in association with breast cancer: Results from a large-scale case-control study. Eur. J. Nutr., 2022, 7, 1-9. doi: 10.1007/s00394-022-02811-4. DOI: https://doi.org/10.1007/s00394-022-02811-4

Çetin, Z., Saygili, E.İ., Benlier, N., Ozkur, M. and Sayin, S. Omega-3 Polyunsaturated Fatty Acids and Cancer. In Nutraceuticals and Cancer Signaling. Springer, Cham., 2021, 591-631. https://doi.org/10.1007/978-3-030-74035-1_22. DOI: https://doi.org/10.1007/978-3-030-74035-1_22

Mukerjee, S., Saeedan, A.S., Ansari, M. and Singh, M. Polyunsaturated fatty acids mediated regulation of membrane biochemistry and tumor cell membrane integrity. Memb., 2021, 11, 479. https://doi.org/10.3390/membranes11070479. DOI: https://doi.org/10.3390/membranes11070479

Purcell, S.A., Marker, R.J., Cornier, M.A. and Melanson, E.L. Dietary intake and energy expenditure in breast cancer survivors: A review. Nutr., 2021, 13, 3394. doi: 10.3390/nu13103394. DOI: https://doi.org/10.3390/nu13103394

Jeong, S.M. and Park, S.M. Care for breast cancer survivors. In Translational Research in Breast Cancer. Springer, Singapore., 2021. https://doi.org/10.1007/978-981-32-9620-6_27. DOI: https://doi.org/10.1007/978-981-32-9620-6_27

Xu, K., Peng, R., Zou, Y., Jiang, X., Sun, Q. and Song, C. Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses. Int. J. Fd. Sci. Nutr., 2022, 15, 1-2. https://doi.org/10.1080/09637486.2022.2048359. DOI: https://doi.org/10.1080/09637486.2022.2048359

Bernhardt, S.M., Borges, V.F. and Schedin, P. Vitamin D as a potential preventive agent for young women’s breast cancer. Cancer Prev Res., 2021, 14, 825-838. https://doi.org/10.1158/1940-6207.CAPR-21-0114. DOI: https://doi.org/10.1158/1940-6207.CAPR-21-0114

Williams, C.P., Gallagher, K.D., Deehr, K., Aswani, M.S., Azuero, A., Daniel, C.L., Ford, E.W., Ingram, S.A., Balch, A.J. and Rocque, G.B. Quantifying treatment preferences and their association with financial toxicity in women with breast cancer. Cancer., 2021, 127, 449-57. https://doi.org/10.1002/cncr.33287. DOI: https://doi.org/10.1002/cncr.33287

Álvaro Sanz, E., Abilés, J., Garrido Siles, M., Pérez Ruíz, E., Alcaide García, J. and Rueda Domínguez, A. Impact of weight loss on cancer patients’ quality of life at the beginning of the chemotherapy. Support Care in Cancer., 2021, 29, 627-634. https://doi.org/10.1007/s00520-020-05496-9 DOI: https://doi.org/10.1007/s00520-020-05496-9

Lohmann, A.E., Soldera, S.V., Pimentel, I., Ribnikar, D., Ennis, M., Amir, E. and Goodwin, P.J. Association of obesity with breast cancer outcome in relation to cancer subtypes: A meta-analysis. J. Natl. Cancer Inst., 2021, 113, 1465-1475. https://doi.org/10.1093/jnci/djab023. DOI: https://doi.org/10.1093/jnci/djab023

Liu, L., Wu, Y., Cong, W., Hu, M., Li, X. and Zhou, C. Experience of women with breast cancer undergoing chemotherapy: A systematic review of qualitative research. Qual. Life Res., 2021, 30, 1249-65. doi: 10.1007/s11136-020-02754-5. DOI: https://doi.org/10.1007/s11136-020-02754-5

But-Hadzic, J., Dervisevic, M., Karpljuk, D., Videmsek, M., Dervisevic, E., Paravlic, A., Hadzic, V. and Tomazin, K. Six-minute walk distance in breast cancer survivors-A systematic review with meta-analysis. Int. J. Environ. Res. Public Health., 2021, 18, 2591. doi: 10.3390/ijerph18052591. DOI: https://doi.org/10.3390/ijerph18052591

De Cicco, P., Catani, M.V., Gasperi, V., Sibilano, M., Quaglietta, M. and Savini, I. Nutrition and breast cancer: A literature review on prevention, treatment and recurrence. Nutr., 2019, 11, 1514. https://doi.org/10.3390/nu11071514. DOI: https://doi.org/10.3390/nu11071514

Berkey, C.S., Tamimi, R.M., Willett, W.C., Rosner, B., Hickey, M., Toriola, A.T., Frazier, A.L. and Colditz, G.A. Adolescent alcohol, nuts and fiber: Combined effects on benign breast disease risk in young women. NPJ. Breast Cancer., 2020, 6, 1-5. https://doi.org/10.1038/s41523-020-00206-4. DOI: https://doi.org/10.1038/s41523-020-00206-4

Daly, A.A., Rolph, R., Cutress, R.I. and Copson, E.R. A review of modifiable risk factors in young women for the prevention of breast cancer. Breast Cancer: Targets. Ther., 2021, 13, 241. doi: 10.2147/BCTT.S268401. DOI: https://doi.org/10.2147/BCTT.S268401

Hwang, E.S. and Nho, J.H. Lifestyle intervention for breast cancer women. J. Lifestyle Med., 2019, 9, 12. doi: 10.15280/jlm.2019.9.1.12. DOI: https://doi.org/10.15280/jlm.2019.9.1.12

YildizKabak, V., Gursen, C., Aytar, A., Akbayrak, T. and Duger, T. Physical activity level, exercise behavior, barriers, and preferences of patients with breast cancer-related lymphedema. Support. Care in Cancer., 2021, 29, 3593-3602. https://doi.org/10.1007/s00520-020-05858-3. DOI: https://doi.org/10.1007/s00520-020-05858-3

Lunar, K.G., Kozjek, N.R. and Kovac, M.B. Changes in eating habits in breast cancer patients. Slovenian J. Pub. Health., 2021, 60, 65-71. https://doi.org/10.2478/sjph-2021-0010. DOI: https://doi.org/10.2478/sjph-2021-0010

Bahinipati, J., Sarangi, R., Mishra, S. and Mahapatra, S. Nutrigenetics and nutrigenomics: A brief review with future prospects. Biomed., 2021, 41, 714-719. https://doi.org/10.51248/.v41i4.445. DOI: https://doi.org/10.51248/.v41i4.445

Archibald, A. and Joffe, Y. The Role of Nutrigenetics and nutrigenomics in clinical nutrition practice. ADCES in Practice., 2021, 9, 34-40. https://doi.org/10.1177/2633559X20984137. DOI: https://doi.org/10.1177/2633559X20984137

Ahluwalia, M.K. Nutrigenetics and nutrigenomics- A personalized approach to nutrition. Adv. Genet., 2021, 108, 277-340. https://doi.org/10.1016/bs.adgen.2021.08.005. DOI: https://doi.org/10.1016/bs.adgen.2021.08.005

Sellami, M. and Bragazzi, N.L. Nutrigenomics and breast cancer: State-of-art, future perspectives and insights for prevention. Nutr., 2020, 12, 512. https://doi.org/10.3390/nu12020512. DOI: https://doi.org/10.3390/nu12020512

Clinton, S.K., Giovannucci, E.L. and Hursting, S.D. The world cancer research fund/American institute for cancer research third expert report on diet, nutrition, physical activity, and cancer: Impact and future directions. J. Nut., 2020, 150, 663-671. https://doi.org/10.1093/jn/nxz268. DOI: https://doi.org/10.1093/jn/nxz268

Steck, S.E. and Murphy, E.A. Dietary patterns and cancer risk. Nat. Rev. Cancer., 2020, 20, 125-138. https://doi.org/10.1038/s41568-019-0227-4. DOI: https://doi.org/10.1038/s41568-019-0227-4

Kontou, N. The Mediterranean Diet in Cancer Prevention. In The Mediterranean Diet; Preedy, V.R., Watson, R.R., Eds.; Academic Press: San Diego, CA, USA, 2015, 393-406. https://doi.org/10.3390/nu11071514. DOI: https://doi.org/10.1016/B978-0-12-407849-9.00036-1

Skouroliakou, M., Grosomanidis, D., Massara, P., Kostara, C., Papandreou, P., Ntountaniotis, D. and Xepapadakis, G. Serum antioxidant capacity, biochemical profile and body composition of breast cancer survivors in a randomized Mediterranean dietary intervention study. Eur. J. Nutr., 2018, 57, 2133-2145. https://doi.org/10.3390/nu11071514. DOI: https://doi.org/10.1007/s00394-017-1489-9

Masala, G., Assedi, M., Bendinelli, B., Ermini, I., Sieri, S., Grioni, S., Sacerdote, C., Ricceri, F., Panico, S. and Mattiello, A. Fruit and vegetables consumption and breast cancer risk: The EPIC Italy study. Breast Cancer Res. Treat., 2012, 132, 1127-1136. https://doi.org/10.1007/s10549-011-1939-7. DOI: https://doi.org/10.1007/s10549-011-1939-7

Fink, B.N., Gaudet, M.M., Britton, J.A., Abrahamson, P.E., Teitelbaum, S.L. and Jacobson, J. Fruits, vegetables, and micronutrient intake in relation to breast cancer survival. Breast Cancer Res. Treat., 2006, 98, 199-208. https://doi.org/10.1007/s10549-005-9150-3. DOI: https://doi.org/10.1007/s10549-005-9150-3

Bissonauth, V., Shatenstein, B. and Ghadirian, P. Nutrition and breast cancer among sporadic cases and gene mutation carriers: An overview. Cancer Detect. Prev., 2008, 32, 52-64. https://doi.org/10.1016/j.cdp.2008.01.005. DOI: https://doi.org/10.1016/j.cdp.2008.01.005

Ericson, U., Sonestedt, E. and Ivarsson, M.I. Folate intake, methylene tetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmo Diet and Cancer cohort. Cancer Epidemiol. Biomark. Prev., 2009, 18, 1101-10. https://doi.org/10.1158/1055-9965.EPI-08-0401. DOI: https://doi.org/10.1158/1055-9965.EPI-08-0401

Li, Y., Yuan, Y.Y., Meeran, S.M. and Tollefsbol, T.O. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ER α-negative breast cancer cells. Mol. Cancer., 2010, 9, 274. https://doi.org/10.1186/1476-4598-9-274. DOI: https://doi.org/10.1186/1476-4598-9-274

Lee, S.A., Fowke, J.H., Lu, W., Ye, C., Zheng, Y. and Cai, Q. Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk. Am. J. Clin. Nutr., 2008, 87, 753-760. DOI: https://doi.org/10.1093/ajcn/87.3.753

Syed Alwi, S.S., Cavell, B.E., Telang, U., Morris, M.E, Parry, B.M. and Packham, G. In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: A pilot study. Br. J. Nutr., 2010, 104, 1288-1296. doi:10.1017/S0007114510002217. DOI: https://doi.org/10.1017/S0007114510002217

Wang, J., John, E. and Ingles, S.E. 5-lipoxygenase and 5-lipoxygenase- activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. Cancer Epidemiol. Biomark. Prev., 2008, 17, 2748-2754. https://doi.org/10.1158/1055-9965.EPI-08-0439. DOI: https://doi.org/10.1158/1055-9965.EPI-08-0439

Dimri, M., Bommi, P.V., Sahasrabuddhe, A.A., Khandekar, J.D. and Dimri, G.P. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. Carcinogenesis., 2010, 31, 489-495. https://doi.org/10.1093/carcin/bgp305. DOI: https://doi.org/10.1093/carcin/bgp305

Li, Y., Ambrosone, C.B., McCullough, M.J., Ahn, J., Stevens, V.L., Thun, M.J. and Hong, C.C. Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. Carcinogenesis., 2009, 30, 777-784. https://doi.org/10.1093/carcin/bgp053. DOI: https://doi.org/10.1093/carcin/bgp053

Iwasaki, M., Hamada, G.S., Nishimoto, I.N., Netto, M.M., MotolaJr, J. and Laginha, F.M. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17betaHSD1, and SHBG genes and risk of breast cancer in case- control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians. Nutr. Cancer., 2010, 62, 466-475. https://doi.org/10.1080/01635580903441279. DOI: https://doi.org/10.1080/01635580903441279

Qin,W., Zhu, W., Shi, H., Hewett, J.E., Ruhlen, R.L. and MacDonald, R.S. Soy isoflavones have an antiestrogenic effect and alter mammary promoter hypermethylation in healthy premenopausal women. Nutr. Cancer., 2009, 61, 238-244. https://doi.org/10.1080/01635580802404196. DOI: https://doi.org/10.1080/01635580802404196

Jawaid, K., Crane, SR., Nowers, J.L., Lacey, M. and Whitehead, S.A. Long-term genistein treatment of MCF-7 cells decreases acetylated histone 3 expression and alters growth responses to mitogens and histone deacetylase inhibitors. J. Steroid Biochem. Mol. Biol., 2010, 120, 164-171. https://doi.org/10.1016/j.jsbmb.2010.04.007. DOI: https://doi.org/10.1016/j.jsbmb.2010.04.007

Colomer, R. and Menendez, JA. Mediterranean diet, olive oil and cancer. Clin. Transl. Oncol., 2006, 8, 15-21. https://doi.org/10.1007/s12094-006-0090-0. DOI: https://doi.org/10.1007/s12094-006-0090-0

Yuan, J.M., Koh, W.P. and Sun, C.L. Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore. Carcinogenesis., 2005, 26, 1389-1394. https://doi.org/10.1093/carcin/bgi080. DOI: https://doi.org/10.1093/carcin/bgi080

Menéndez, J.A., Vázquez-Martin, A., Ropero, S., Colomer, R. and Lupu, R. HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alphalinolenic acid (ALA; 18:3n-3) in breast cancer cells: The “fat features” of the “Mediterranean diet” as an “anti-HER2 cocktail”. Clin. Transl. Oncol., 2006, 8, 812-820. https://doi.org/10.1007/s12094-006-0137-2. DOI: https://doi.org/10.1007/s12094-006-0137-2

Augimeri ,G., Montalto, F.I., Giordano, C., Barone, I., Lanzino, M., Catalano, S., Andò, S., De Amicis, F. and Bonofiglio, D. Nutraceuticals in the Mediterranean Diet: Potential avenues for breast cancer treatment. Nutr., 2021, 13, 2557. https://doi.org/10.3390/nu13082557. DOI: https://doi.org/10.3390/nu13082557

Mierziak, J., Kostyn, K., Boba, A., Czemplik, M., Kulma, A. and Wojtasik, W. Influence of the bioactive diet components on the gene expression regulation. Nutr., 2021, 13, 3673. https://doi.org/10.3390/nu13113673. DOI: https://doi.org/10.3390/nu13113673

Liu, R.H. Health-promoting components of fruits and vegetables in the diet. Adv. Nutr., 2013, 4, 384-392. https://doi.org/10.3945/an.112.003517. DOI: https://doi.org/10.3945/an.112.003517

Schuchardt, J.P., Huss, M., Stauss-Grabo, M. and Hahn, A. Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur. J. Pediat., 2010, 169, 149-164. https://doi.org/10.1007/s00431-009-1035-8. DOI: https://doi.org/10.1007/s00431-009-1035-8

Samtiya, M., Aluko, R.E., Dhewa, T. and Moreno-Rojas, J.M. Potential health benefits of plant food-derived bioactive components: An overview. Fds., 2021, 10, 839. https://doi.org/10.3390/foods10040839. DOI: https://doi.org/10.3390/foods10040839

George, B.P. and Abrahamse, H. Increased oxidative stress induced by rubus bioactive compounds induce apoptotic cell death in human breast cancer cells. Oxid. Med. Cell. Longev., 2019. https://doi.org/10.1155/2019/6797921. DOI: https://doi.org/10.1155/2019/6797921



How to Cite

K, S., & S, S. (2022). A Comprehensive Review on Role of Nutrition in Management of Breast Cancer. The Indian Journal of Nutrition and Dietetics, 59(4), 506–523. https://doi.org/10.21048/IJND.2022.59.4.30271



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