TY - JOUR AU - Ansarullah, AU - Ramachandran, A. V. PY - 2023/03/10 Y2 - 2024/03/29 TI - Pancreatic β-Cell Dysfunction in Diabetes JF - Journal of Endocrinology and Reproduction JA - JER VL - 26 IS - 4 SE - Review Article DO - 10.18311/jer/2022/32055 UR - https://informaticsjournals.com/index.php/jer/article/view/32055 SP - 207-212 AB - <p>The decline in functional β-cell mass and β-cell dysfunction causes diabetes. Pancreatic β-cells play a fundamental role in controlling the glucose milieu, and β-cells of diabetic patients poorly respond to glucose. The mechanism underlying the pathology of impaired β-cell function is a unique challenge. This concise review summarizes the identity of β-cells during the progression and established diabetes. Understanding β-cell heterogeneity and the dynamic functional state during health and disease progression would be important for designing diabetes therapeutics to restore the β-cell mass by cellreplacement or regeneration approaches.</p> ER -