Cholesterol Lowering Effects Of Psyllium Husk


Affiliations

  • Health Total Pvt. Ltd., Mumbai, India

Abstract

Psyllium or isabgol is a soluble fibre that comes from a herb called Plantago ovata, most commonly used as a gentle laxative. Husk is derived from the thousands of tiny gel-coated seeds of psyllium plant. Being a great laxative, it can help relieve diarrhea and constipation issues, along with treating intestinal problems like irritable bowel syndrome. Several large-scale, population-based studies suggest that the soluble fibre of psyllium can help lower cholesterol and has also been used to help regulate blood sugar levels in people with diabetes. Psyllium husk acts by forming a gelatin-like structure when it comes in contact with water, that traps waste and helps in its transport through the intestinal tract.

Keywords

Psyllium husk, fibre, cholesterol

Full Text:

References

Petchetti L, Frishman WH, Petrillo R, Raju K. Nutriceuticals in cardiovascular disease: psyllium. Cardiol Rev. 2007. 15: 116–122.

Bandopadhyay PC. Viscometric investigations in high polymeric acids, acid polysaccharides from Plantago ovata. Journal of Scientific & Industrial Research. 1961. 20: 101-104.

Anon. The Wealth of India - Raw Materials Vol. VIII, Council of Scientific and Industrial Research, New Delhi, India. 1989. 146-154.

Sharma VK, Bhattacharya A. Isabgol Husk: A Herbal Remedy for Human. Health. Journal of Pharmacy Research. 2009. 2(2): 296-301.

Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation:systematic review. Am J Gastroenterol. 2005. 100: 936–971.

Washington N, Harris M, Mussellwhite A, Spiller RC. Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation. Am J Clin Nutr. 1998. 67: 317–321.

Fernandez-Banares F, Hinojosa J, SanchezLombrana JL, Navarro E, Martinez-Salmeron JF, Garcia-Puges A, et al. Randomized clinical trial of Plantago ovata seeds (dietary fibre) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU). Am J Gastroenterol. 1999. 94: 427–433.

Pittler MH, Ernst E. Dietary supplements for body-weight reduction: a systematic review. Am J Clin Nutr. 2004. 79: 529–536.

Moreyra AE, Wilson AC, Koraym A. Effect of combining psyllium fibre with simvastatin in lowering cholesterol. Arch Int Med. 2005. 165: 1161–1166.

Anderson JW, Allgood LD, Turner J, Oeltgen PR, Daggy B.P. Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia. Am J Clin Nutr. 1999. 70: 466–473.

Anderson JW, Allgood LD, Lawrence A, Altringer LA, Jerdack GR, Hengehold DA. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: metaanalysis of 8 controlled trials. Am J Clin Nutr. 2000. 71: 472–479.

Gupta RR, Argawal CG, Singh GP, Ghatak A. Lipid-lowering efficacy of psyllium hydrophilic mucilloid in non insulin dependent diabetes mellitus with hypercholesterolemia. Indian J Med Res. 1994. 100: 237–241.

Fukagawa NK, Anderson JW, Hageman G, Young VR, Minaker KL. High-carbohydrate, high-fibre diets increase peripheral insulin sensitivity in healthy young and old adults. Am J Clin Nutr. 1990. 52: 524–528.

Pastors JG, Blaisdell PW, Balm TK, Asplin CM, Pohl SL. Psyllium fibre reduces rise in postprandial glucose and insulin concentrations in patients with noninsulin-dependent diabetes. Am J Clin Nutr. 1991. 53: 1431–1435.

Garvin JE, Forman DT, Eiseman WR, Phillips CR. Lowering of serum cholesterol by oral hydrophilic colloid. Proc Soc Exp Biol Med. 1965. 120: 744–746.

Anderson JW, Zettwoch N, Feldman T, Tietyen-Clark J, Oeltgen P, Bishop CW. Cholesterol-lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemia. Arch Intern Med. 1988. 148: 292–296.

Rodríguez-Cabezas ME, Gálvez J, Camuesco D, Lorente MD, Concha A, Martinez-Augustin, O, Redondo L, Zarzuelo A. Intestinal anti-inflammatory activity of dietary fibre (Plantago ovata seeds) in HLA-B27 transgenic rats. Clinical nutrition. 2003. 22(5): 463-471.

Davidson MH, Dugan LD, Burns JH, Sugimoto D, Story K, Drennan K. A psylliumenriched cereal for the treatment of hypercholesterolemia in children: a controlled double-blind, crossover study. Am J Clin Nutr. 1996. 63: 96–102.

McCall MR, Mehta T, Leathers CW, Foster DM. Psyllium husk I: Effect on plasma lipoproteins, cholesterol metabolism, and atherosclerosis in African green monkeys. Am J Clin Nutr. 1992. 56: 376–384.

Van Rosendaal GMA, Shaffer EA, Alun LE, Brant R. Effect of administration on cholesterol-lowering by psyllium: a randomized cross-over study in normocholesterolemic or slightly hypercho-lesterolemic subjects. Nutr J. 2004. 28: 3–17.

Matheson HB, Colon IS, Story JA. Cholesterol 7-hydroxylase activity is increased by dietary modification with psyllium hydrocolloid, pectin, cholesterol and cholestyramine in rats. J Nutr. 1995. 125: 454–458.

Carr TP, Gallaher DD, Yang JK, Hassel CA. Increased intestinal contents viscosity reduces cholesterol absorption efficiency in hamsters fed hydroxypropyl methylcellulose. J Nutr. 1996. 126: 1463–1469.

Gallaher DD, Hassel CA, Lee KJ. Relationships between viscosity of hydroxypropyl methylcellulose and plasma cholesterol in hamsters. J Nutr. 1993. 123: 1732–1738.

Williams CL, Bollella M, Spark A, Puder D. Soluble fibre enhances the hypocholesterolemic effect of the step I diet in childhood. J Am Coll Nutr. 1995. 14(3): 251-257. Page No.13

Sprecher DL, Harris BV, Goldberg AC, Anderson EC, Bayuk LM, Russell BS et al. Efficacy of psyllium in reducing serum cholesterol levels in hypercholesterolemic patients on high or low-fat diets. Ann Intern Med. 1993. 119: 545–554.

Uehleke B, Ortiz M, Stange R. Cholesterol reduction using psyllium husks - do gastrointestinal adverse effects limit compliance? Results of a specific observational study. Phytomedicine. 2008. 15(3): 153-159.

Ziai SA, Larijani B, Akhoondzadeh S, Fakhrzadeh H, Dastpak A, Bandarian F, Rezai A, Badi HN, Emami T. Psyllium decreased s erum g lucos e and g l ycosy l ated hemoglobin significantly in diabetic outpatients. J Ethnopharmacol. 2005. 102: 202–207.


Refbacks

  • There are currently no refbacks.