Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats


  • Bandung Institute of Technology, School of Phrmacy, Bandung, 40132, Indonesia


Garcinia mangostana L.has been used as an antioxidant to inhibit oxidation of low density lipoproteins and as an antiobesity agent. The aim of this study was to evaluate the effect of a Mangosteen (G. mangostana L.) Pericarp Ethanolic Extract (MPEE) on lipid profile in rats fed with high-fat diet.The experimental study was conducted in male Wistar rats for 4 weeks and 9 weeks, with rats divided into 5 treatment groups which were normal (standard diet), control (high-fat diet), dose 1 (high-fat diet, MPEE 200 mg/kg b.w.), dose 2 (high-fat diet, MPEE 500 mg/kg b.w.), and orlistat (high-fat diet, orlistat 21.6 mg/kg b.w.) groups. The serum concentration of cholesterol High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) and triglycerides of all the animals in each group were determined after the 4 weeks and 9 weeks of treatment. Intrygliceride level, MPEE at the dose of 500 mg/kgbw was more active than the dose of 200mg/kg. The rats treated with MPEE significantly decreased the LDL level in the 9 weeks at the dose of 200 mg/kg bw and 500 mg/kg bw. However, the HDL level amongthe all groups showed no significant difference.Mangosteen Pericarp Ethanolic Extract (MPEE) has potential as anti-obesity drugs by lowering the tryglyceride and LDL level in high-fat Wistar rats.


Mangosteen, Obesity, Triglyceride, HDL, LDL

Subject Discipline


Full Text:


Seidell JC, Halberstadt J. The global burden of obesity and the challenges of prevention. Ann Nutr Metab. 2015; 66(2):7–2. Crossref. PMid:26045323

Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the global burden of disease study 2013. Lancet. 2014; 384(9945):766–1. Crossref.

Konturek SJ, Konturek JW, Pawlik T, Brzozowski T. Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol. 2004; 55(1 Pt 2):137–4. PMid:15082874

Nawrot-Porabka K, Jaworek J, Leja-Szpak A, Palonek M, Szklarczyk J, Konturek SJ. Leptin Is able to stimulate pancreatic enzyme secretion via activation of duodeno-pancreatic reflex and cck release. J Physiol Pharmacol. 2004;55:47–7. PMid:15608360

Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000; 404(6778):661–1. Crossref. PMid:10766253

Bajari TM, Nimpf J, Schneider WJ. Role of leptin inreproduction. J Curr Opin Lipido. 2004; 15:315–9. Crossref.

Yun J. Possible anti-obesity therapeutic from nature-a review. Phytochem. 2010; 71(14-15):1625–1. Crossref. PMid:20732701

Widowati W, Darsono L, Suherman J, Fauziah N, Maesaroh M, Erawijantari PP. Anti-inflammatory effect of mangosteen (Garcinia mangostana L.) peel extract and its compounds in LPS-induced RAW 264.7 Cells. Nat Prod Sci. 2016; 22(3):147–3. Crossref.

Kang J, Park C. Anti-obesity drugs: A review about their effects and safety. Diabetes Metab J. 2012; 36:13–5. Crossref. PMid:22363917 PMCid: PMC3283822

Liu Q, Wang Y, Lin L. New insights into the antiobesity activity of xanthones from Garcinia mangostana. Food Funct. 2015;6:383–3. Crossref. PMid:25520256

Pedraza-Chaverrí J, Cárdenas-Rodríguez N, OrozcoIbarra M, Pérez-Rojas JM. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol. 2008; 46:3227–9. Crossref. PMid: 18725264

Akao Y, Nakagawa Y, Iinuma M, Nozawa Y. Anticancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci. 2008; 9:355–70. Crossref. PMid:19325754 PMCid:PMC2635669

Cui J, Hu W, Cai Z, Liu Y, Li S, Tao W et al. New medicinal properties of mangostins: Analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L. Pharmacol Biochem Behav. 2010; 95:166–2. Crossref. PMid:20064550

Widowati W, Darsono L, Suherman J, Yelliantty Y, Maesaroh M. High Performance Liquid Chromatography (HPLC) analysis, antioxidant, antiaggregation of mangosteen peel extract (Garcinia mangostana L.). Int J Biosci Biochem Bioinform. 2014; 4(6):458–6. Crossref.

Larter CZ, Yeh MM. Animal models of NASH: Getting both pathology and metabolic context right. J Gastroenterol Hepatol. 2008; 23:1635–8. Crossref.PMid:18752564

Brosnan JT, Drewnowski A, Friedman M.I. Erratum to: Is there a relationship between dietary MSG and obesity in animals or humans? Amino Acid. 2014; 46(9):2089–9. Crossref. PMid:24927698

Shibata M, Iinuma M, Morimoto J, Kurose H, Akamatsu K, Okuno Y, et al. α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med. 2011; 9(69):1–8.

Abuzaid AS, Iskandar EY, Kurniati NF, Adnyana IK. Prevention of obesity and development of metabolic syndrome by mangosteen (Garcinia mangostana L.) pericarp ethanolic extract in male wistar rats fed with high-fat diet. IJPPS. 2016a; 8(5): 1–7.

Adnyana IK, Abuzaid AS, Iskandar EY, Kurniati NF.Pancreatic lipase and α-amylase inhibitory potential of mangosteen (Garcinia mangostana Linn.) pericarp extract. Int J Med Res Health Sci. 2016; 5(1):23–8.Crossref.

Hu D, Hannah J, Gray RS, Jablonski KA, Henderson JA, Robbins DC, et al. Effects of obesity and body fat distribution on lipids and lipoproteins in nondiabetic American Indians: The strong heart study. Obes Res.2000; 8(6):411–1. Crossref. PMid:11011907

Bray GA. Obesity: The disease. J Med Chem. 2006; 49(14):4001–7. Crossref. PMid:16821759

Lois K, Kumar S. Obesity and diabetes. Endocrinol Nutr. 2009; 56(4):38–2. Crossref.

Kang J, Nam D, Kim K, Huh J, Lee J. Effect of Gambisan on the inhibition of adipogenesis in 3T3L1 adipocytes. J Evid Based Complementary Altern Med. 2013; 2013:1–1. Crossref. PMid:23589718 PMCid:PMC3622388

Lee YJ, Choi DH, Cho GH, Kim JS, Kang DG, Lee HS. Arctium lappa ameliorates endothelial dysfunction in rats fed with fat/cholesterol diets. BMC Compl Altern Med. 2012;12:116–5. Crossref. PMid:22866890 PMCid:PMC3517347

e Silva MAA, Vechetti-Junior IJ, do Nascimento AF, Furtado KS, Azevedo L, Ribeiro DA et al. Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet. Appl Physiol Nutr Metab. 2012; 37:1101–9. Crossref. PMid:22957766

Abuzaid AS, Iskandar EY, Kurniati NF, Adnyana IK. Preventive effect on obesity of mangosteen (Garcinia mangostanaL.) pericarp ethanolic extract by reduction of fatty acid synthase level in monosodium glutamate and high-calorie diet-induced male wistar rats. Asian J Pharm Clin Res. 2016; 9(3):257–60.

Edwar Z, Suyuthie H, Yerizel E, Sulastri D. Pengaruh pemanasan terhadap kejenuhan asam lemak minyak goreng sawit dan minyak goreng jagung. J Indonesian Med Assoc. 2011; 61(6):248–2.

McLaren JE, Michael DR, Ashlin TG, Ramji DP. Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy. Prog Lipid Res. 2011; 50(4):331–7. Crossref.PMid:21601592

Adiputro DL, Widodo MA, Romdoni R, Sargowo D. Extract of mangosteen increases high density lipoprotein levels in rats fed high lipid. Universa Medicina. 2013; 32(1):37–3.

Wihastuti TA, Widodo MA, Heriansyah T, Sari NAK. Study of the inhibition effect of ethanolic extract of mangosteen pericarp on atherogenesis in hypercholesterolemic rat. Asian Pac J Trop Dis. 2015; 5(10):830–4. Crossref.

Rashid S, Genest J. Effect of obesity on high-density lipoprotein metabolism. Obese. 2007; 15(12):2875– 8. Crossref. PMid:18198293

Barter PJ, Kastelein JJP. Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease. 2006; 47(3):492–9.


  • There are currently no refbacks.